Investig Clin Urol.  2023 Sep;64(5):501-509. 10.4111/icu.20220377.

First-morning urine osmolality and nocturnal enuresis in children: A single-center prospective cohort study

• Lee GK
• Chung JM
• Lee SD

• KMID: 2545569
• DOI: http://doi.org/10.4111/icu.20220377

Abstract

Purpose
To investigate the treatment outcome of nocturnal enuresis (NE) according to first-morning urine osmolality (Uosm) before treatment.
Materials and Methods
Ninety-nine children (mean age, 7.2±2.1 y) with NE were enrolled in this retrospective study and divided into two groups according to first-morning Uosm results, that is, into a low Uosm group (<800 mOsm/L; 38 cases, 38.4%) or a high Uosm group (≥800 mOsm/L; 61 cases, 61.6%). Baseline parameters were obtained from frequency volume charts of at least 2 days, uroflowmetry, post-void residual volume, and a questionnaire for the presence of frequency, urgency, and urinary incontinence. Standard urotherapy and pharmacological treatment were administered initially in all cases. Enuresis frequency and response rates were analyzed at around 1 month and 3 months after treatment initiation.
Results
The level of first-morning Uosm was 997.1±119.6 mOsm/L in high Uosm group and 600.9±155.9 mOsm/L in low Uosm group (p<0.001), and first-morning voided volume (p=0.021) and total voided volume (p=0.019) were significantly greater in the low Uosm group. Furthermore, a significantly higher percentage of children in the low Uosm group had a response rate of ≥50% (CR or PR) at 1 month (50.0% vs. 24.6%; p=0.010) and 3 months (63.2% vs. 36.1%; p=0.009).
Conclusions
Treatment response rates are higher for children with NE with a lower first-morning Uosm.

Keyword

Child; Nocturnal enuresis; Osmolar concentration; Urinalysis; Urinary bladder