Korean J Gastroenterol.  2023 Aug;82(2):73-83. 10.4166/kjg.2023.079.

Impact of Diet on Colorectal Cancer Progression and Prevention: From Nutrients to Neoplasms

• Kim SH
• Park DH
• Lim YJ

• KMID: 2545331
• DOI: http://doi.org/10.4166/kjg.2023.079

Abstract

Colorectal cancer (CRC), one of the most common cancers worldwide, continues to increase in incidence and mortality rates. This trend is closely linked to changes in dietary habits, which are major risk factors for colorectal cancer. The increase in the incidence of CRC in countries previously considered low-risk and with low socioeconomic status is most likely due to lifestyle and dietary changes. Understanding the influence of dietary factors on the onset of colorectal cancer is essential for prevention and treatment. This review explores the complex interplay between dietary factors and colorectal cancer, focusing on the key nutrients and dietary habits that influence disease onset and progression. The impact of diet on colorectal microbiota and the influence of diet on early-onset colorectal cancer are also reviewed, reviewing recent research on how dietary interventions affect the treatment and recurrence of colorectal cancer. Finally, the future research directions for developing and applying effective dietary intervention strategies are discussed.

Keyword

Colorectal neoplasms; Nutritional sciences; Microbiota

Figure

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  Fig. 1 Pathophysiological mechanism involved in colorectal carcinogenesis and the role of dietary nutrients. VDR, vitamin D receptor.

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