Epidemiol Health.
2023;45(1):e2023034. 10.4178/epih.e2023034.
The association between obesity and glaucoma in older adults: evidence from the China Health and Retirement Longitudinal Study
- Zhao X
1,2,3 - Bo Q1,2,3
- Sun J1,2,3
- Chen J1,2,3
- Li T1,2,3
- Huang X1,2,3
- Zhou M1,2,3
- Wang J1,2,3
- Liu W1,2,3
- Sun X1,2,3
- Affiliations
-
- 1Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China
- 2National Clinical Research Center for Eye Diseases, Shanghai, China
- 3Shanghai Key Laboratory of Fundus Diseases, Shanghai, China
- KMID: 2545047
- DOI: http://doi.org/10.4178/epih.e2023034
Abstract
OBJECTIVES
This study evaluated the association between obesity and glaucoma in middle-aged and older people. A population-based retrospective cohort study was conducted using data from the China Health and Retirement Longitudinal Study.
METHODS
Glaucoma was assessed via self-reports. Multivariate logistic regression analysis and a Cox proportional hazards model were used to assess the relationship between obesity and glaucoma risk.
RESULTS
Older males living in urban areas who were single, smokers, and non-drinkers were found to have a significantly higher incidence of glaucoma (all p<0.05). Diabetes, hypertension, and kidney disease were also associated with higher glaucoma risk, while dyslipidemia was associated with lower risk (all p<0.05). After the model was adjusted for demographic, socioeconomic, and health-related variables, obesity was significantly associated with a 10.2% decrease in glaucoma risk according to the Cox proportional hazards model (hazard ratio, 0.90; 95% confidence interval [CI], 0.83 to 0.97) and an 11.8% risk reduction in the multivariate logistic regression analysis (odds ratio, 0.88; 95% CI, 0.80 to 0.97). A further subgroup analysis showed that obesity was associated with a reduced risk of glaucoma in people living in rural areas, in smokers, and in those with kidney disease (all p<0.05). Obesity also reduced glaucoma risk in people with diabetes, hypertension, or dyslipidemia more than in healthy controls (all p<0.05).
CONCLUSIONS
This cohort study suggests that obesity was associated with a reduced risk of glaucoma, especially in rural residents, smokers, and people with kidney disease. Obesity exerted a stronger protective effect in people with diabetes, hypertension, or dyslipidemia than in healthy people.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The association between glaucoma and all-cause mortality in middle-aged and elderly Chinese people: results from the China Health and Retirement Longitudinal Study
- Health Conditions Sensitive to Retirement and Job Loss Among Korean Middle-aged and Older Adults
- Effects of Different Types of Perceived Social Support on Changes in Subjective Health among Older Adults: A Focus on Gender Differences
- Normalized Creatinine-to-Cystatin C Ratio and Risk of Diabetes in Middle-Aged and Older Adults: The China Health and Retirement Longitudinal Study
- Exploring cognitive trajectories and their association with physical performance: evidence from the China Health and Retirement Longitudinal Study
