Immune Netw.  2023 Apr;23(2):e12. 10.4110/in.2023.23.e12.

Phosphatase Ssu72 Is Essential for Homeostatic Balance Between CD4⁺ T Cell Lineages

• Kim MH
• Lee CW

• KMID: 2544665
• DOI: http://doi.org/10.4110/in.2023.23.e12

Abstract

Ssu72, a dual-specificity protein phosphatase, not only participates in transcription biogenesis, but also affects pathophysiological functions in a tissue-specific manner. Recently, it has been shown that Ssu72 is required for T cell differentiation and function by controlling multiple immune receptor-mediated signals, including TCR and several cytokine receptor signaling pathways. Ssu72 deficiency in T cells is associated with impaired fine-tuning of receptormediated signaling and a defect in CD4⁺ T cell homeostasis, resulting in immune-mediated diseases. However, the mechanism by which Ssu72 in T cells integrates the pathophysiology of multiple immune-mediated diseases is still poorly elucidated. In this review, we will focus on the immunoregulatory mechanism of Ssu72 phosphatase in CD4⁺ T cell differentiation, activation, and phenotypic function. We will also discuss the current understanding of the correlation between Ssu72 in T cells and pathological functions which suggests that Ssu72 might be a therapeutic target in autoimmune disorders and other diseases.

Keyword

Ssu72 phosphatase; CD4-positive T-lymphocytes; Autoimmune diseases; T-cell receptors; Autoimmunity