J Rhinol.  2023 Jul;30(2):57-61. 10.18787/jr.2023.00017.

Association Between Particulate Matter Exposure and Chronic Rhinosinusitis

Affiliations
  • 1Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

Abstract

Chronic rhinosinusitis (CRS) is a relatively common inflammatory disease of the nasal and paranasal sinus mucosa. Several epidemiological studies have established an association between particulate matter (PM) and CRS. Based on those data, PM has emerged as an important environmental factor in the development of CRS. Recent research has investigated the mechanisms and treatment options for CRS caused by PM through cellular experimentation. Therefore, the authors would like to explain the definition of PM, present research investigating the relationship between PM and CRS, and summarize the involved mechanisms reported to date.

Keyword

Particulate matter; Sinusitis; Mechanism

Reference

References

1. World Health Organization. The world health report 2002: reducing risks, promoting healthy life. Geneva: World Health Organization;2002.
2. Loomis D, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, et al. The carcinogenicity of outdoor air pollution. Lancet Oncol. 2013; 14(13):1262–3.
3. Albu S. Chronic rhinosinusitis—an update on epidemiology, pathogenesis and management. J Clin Med. 2020; 9(7):2285.
4. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012; 50(1):1–12.
5. Aalapati S, Ganapathy S, Manapuram S, Anumolu G, Prakya BM. Toxicity and bio-accumulation of inhaled cerium oxide nanoparticles in CD1 mice. Nanotoxicology. 2014; 8(7):786–98.
6. Valavanidis A, Fiotakis K, Vlachogianni T. Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008; 26(4):339–62.
7. Nemmar A, Holme JA, Rosas I, Schwarze PE, Alfaro-Moreno E. Recent advances in particulate matter and nanoparticle toxicology: a review of the in vivo and in vitro studies. Biomed Res Int. 2013; 2013:279371.
8. Mannucci PM, Harari S, Martinelli I, Franchini M. Effects on health of air pollution: a narrative review. Intern Emerg Med. 2015; 10(6):657–62.
9. Nachman KE, Parker JD. Exposures to fine particulate air pollution and respiratory outcomes in adults using two national datasets: a cross-sectional study. Environ Health. 2012; 11:25.
10. Zhang Z, Kamil RJ, London NR, Lee SE, Sidhaye VK, Biswal S, et al. Long-term exposure to particulate matter air pollution and chronic rhinosinusitis in nonallergic patients. Am J Respir Crit Care Med. 2021; 204(7):859–62.
11. Park M, Lee JS, Park MK. The effects of air pollutants on the prevalence of common ear, nose, and throat diseases in South Korea: a national population-based study. Clin Exp Otorhinolaryngol. 2019; 12(3):294–300.
12. Mady LJ, Schwarzbach HL, Moore JA, Boudreau RM, Tripathy S, Kinnee E, et al. Air pollutants may be environmental risk factors in chronic rhinosinusitis disease progression. Int Forum Allergy Rhinol. 2018; 8(3):377–84.
13. Kato A, Schleimer RP, Bleier BS. Mechanisms and pathogenesis of chronic rhinosinusitis. J Allergy Clin Immunol. 2022; 149(5):1491–503.
14. Yang X, Shen S, Deng Y, Wang C, Zhang L. Air pollution exposure affects severity and cellular endotype of chronic rhinosinusitis with nasal polyps. Laryngoscope. 2022; 132(11):2103–10.
15. Leland EM, Zhang Z, Kelly KM, Ramanathan M Jr. Role of environmental air pollution in chronic rhinosinusitis. Curr Allergy Asthma Rep. 2021; 21(8):42.
16. Cho DY, Hunter RC, Ramakrishnan VR. The microbiome and chronic rhinosinusitis. Immunol Allergy Clin North Am. 2020; 40(2):251–63.
17. Padhye LV, Kish JL, Batra PS, Miller GE, Mahdavinia M. The impact of levels of particulate matter with an aerodynamic diameter smaller than 2.5 μm on the nasal microbiota in chronic rhinosinusitis and healthy individuals. Ann Allergy Asthma Immunol. 2021; 126(2):195–7.
18. Shin CH, Byun J, Lee K, Kim B, Noh YK, Tran NL, et al. Exosomal miRNA-19a and miRNA-614 induced by air pollutants promote proinflammatory M1 macrophage polarization via regulation of RORα expression in human respiratory mucosal microenvironment. J Immunol. 2020; 205(11):3179–90.
19. Lee DC, Choi H, Oh JM, Hong Y, Jeong SH, Kim CS, et al. The effect of urban particulate matter on cultured human nasal fibroblasts. Int Forum Allergy Rhinol. 2018; 8(9):993–1000.
20. Sun B, Song J, Wang Y, Jiang J, An Z, Li J, et al. Associations of shortterm PM2.5 exposures with nasal oxidative stress, inflammation and lung function impairment and modification by GSTT1-null genotype: a panel study of the retired adults. Environ Pollut. 2021; 285:117215.
21. Lee HJ, Kim DK. Effect of airborne particulate matter on the immunologic characteristics of chronic rhinosinusitis with nasal polyps. Int J Mol Sci. 2022; 23(3):1018.
22. Zhao R, Guo Z, Dong W, Deng C, Han Z, Liu J, et al. Effects of PM2.5 on mucus secretion and tissue remodeling in a rabbit model of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2018; 8(11):1349–55.
23. Ahmadzada S, Ende JA, Alvarado R, Christensen JM, Kim JH, Rimmer J, et al. Responses of well-differentiated human sinonasal epithelial cells to allergen exposure and environmental pollution in chronic rhinosinusitis. Am J Rhinol Allergy. 2019; 33(6):624–33.
24. Montgomery MT, Sajuthi SP, Cho SH, Everman JL, Rios CL, Goldfarbmuren KC, et al. Genome-wide analysis reveals mucociliary remodeling of the nasal airway epithelium induced by urban PM2.5. Am J Respir Cell Mol Biol. 2020; 63(2):172–84.
25. Lee DC, Choi H, Oh JM, Lee J, Lee J, Lee HY, et al. Urban particulate matter regulates tight junction proteins by inducing oxidative stress via the Akt signal pathway in human nasal epithelial cells. Toxicol Lett. 2020; 333:33–41.
26. London NR Jr, Tharakan A, Rule AM, Lane AP, Biswal S, Ramanathan M Jr. Air pollutant-mediated disruption of sinonasal epithelial cell barrier function is reversed by activation of the Nrf2 pathway. J Allergy Clin Immunol. 2016; 138(6):1736–8.e4.
27. Xian M, Ma S, Wang K, Lou H, Wang Y, Zhang L, et al. Particulate matter 2.5 causes deficiency in barrier integrity in human nasal epithelial cells. Allergy Asthma Immunol Res. 2020; 12(1):56–71.
28. Lee DC, Choi H, Oh JM, Lee DH, Kim SW, Kim SW, et al. Protective effects of α-lipoic acid on cultured human nasal fibroblasts exposed to urban particulate matter. Int Forum Allergy Rhinol. 2019; 9(6):638–47.
29. Lee DC, Oh JM, Choi H, Kim SW, Kim SW, Kim BG, et al. Eupatilin inhibits reactive oxygen species generation via Akt/NF-κB/MAPK signaling pathways in particulate matter-exposed human bronchial epithelial cells. Toxics. 2021; 9(2):38.
30. Lee M, Lim S, Kim YS, Khalmuratova R, Shin SH, Kim I, et al. DEPinduced ZEB2 promotes nasal polyp formation via epithelial-to-mesenchymal transition. J Allergy Clin Immunol. 2022; 149(1):340–57.
31. Ramanathan M Jr, London NR Jr, Tharakan A, Surya N, Sussan TE, Rao X, et al. Airborne particulate matter induces nonallergic eosinophilic sinonasal inflammation in mice. Am J Respir Cell Mol Biol. 2017; 57(1):59–65.
32. Gu W, Hou T, Zhou H, Zhu L, Zhu W, Wang Y. Ferroptosis is involved in PM2.5-induced acute nasal epithelial injury via AMPKmediated autophagy. Int Immunopharmacol. 2023; 115:109658.
Full Text Links
  • JR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr