J Cancer Prev.
2023 Jun;28(2):40-46. 10.15430/JCP.2023.28.2.40.
Baicalein Inhibits αα-Melanocyte-stimulating Hormonestimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells
- Affiliations
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- 1Department of Biochemistry, Jeju National University College of Medicine, Jeju, Korea
- 2Jeju Research Center for Natural Medicine, Jeju National University, Jeju, Korea
- KMID: 2544345
- DOI: http://doi.org/10.15430/JCP.2023.28.2.40
Abstract
- Excessive UVB exposure causes development of both malignant and non-malignant melanoma via the secretion of α-melanocyte-stimulating hormone (α-MSH). We investigated whether baicalein (5,6,7-trihydroxyflavone) could inhibit α-MSH-stimulated melanogenesis. Baicalein prevented UVB- and α-MSH-induced melanin production and attenuated α-MSH-stimulated tyrosinase (monophenol monooxygenase) activity, and expression of tyrosinase and tyrosine-related protein-2. In addition, baicalein prevented melanogenesis and pigmentation via the p38 mitogen-activated protein kinases signaling pathway. These findings suggest that baicalein represents a natural compound for attenuating melanogenesis.
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