Soonchunhyang Med Sci.  2023 Jun;29(1):29-33. 10.15746/sms.23.008.

Human Herpesvirus-8 Positive Multicentric Castleman’s Disease with Complete Response after Rituximab Monotherapy: A Case Report

• Kim JY
• Yoon SY
• Lee MY
• Lee N
• Won JH
• Choi IH
• Kim KM
• Kim KH

• KMID: 2543404
• DOI: http://doi.org/10.15746/sms.23.008

Abstract

Castleman’s disease is a rare non-neoplastic lymphoproliferative disorder of unknown origin. It is classified into unicentric or multicentric based on its anatomical distribution. Multicentric Castleman’s disease can be subdivided according to the presence of human herpesvirus-8 (HHV-8) infection. Castleman’s disease has a rare incidence, and HHV-8-positive multicentric Castleman’s disease is even rarer. There are several types of natural course for this disease, and the rapidly progressing type can lead to death within a few weeks, emphasizing the need for prompt diagnosis and treatment. We report a recent case from Korea, presenting with multiple lymphadenopathies, confirmed as HHV-8-positive multicentric Castleman’s disease through biopsy, and achieving complete response with rituximab monotherapy.

Keyword

Human herpesvirus-8; Multi-centric Castleman’s disease; Rituximab; Case report