J Vet Sci.  2023 May;24(3):e36. 10.4142/jvs.22266.

Lymphopenia predicts reduced survival in canine hepatocellular carcinoma

• Suarez-Rodriguez JI
• Liu CC
• Dehghanpir S
• Johnston AN

• KMID: 2542993
• DOI: http://doi.org/10.4142/jvs.22266

Abstract

Platelet to lymphocyte ratio (PLR) is a prognostic marker in human hepatocellular carcinoma (HCC) however, its utility in canine HCC has not been explored. The aim of the study was to determine if PLR could predict survival outcomes in 42 dogs with HCC. PLR was not a significant predictive factor (p = 0.15) but lymphopenia alone was significantly correlated with a reduced probability of survival (p = 0.024). Further studies are needed to evaluate if peripheral lymphocyte count mirrors that of the tumor microenvironment in canine HCC.

Keyword

Liver; cancer; dogs; carcinoma; hepatocellular; tumor microenvironment