J Cardiovasc Imaging.
2023 Apr;31(2):71-82. 10.4250/jcvi.2022.0080.
Dynamic Cardiac Magnetic Resonance Fingerprinting During Vasoactive Breathing Maneuvers: First Results
- Affiliations
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- 1Research Institute of the McGill University Health Center, Montreal, QC, Canada
- 2Department of Cardiology, Amsterdam UMC, Amsterdam, The Netherlands
- 3Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
- 4Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
- 5Department of Anaesthesiology and Pain Medicine, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland
- 6Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA
- 7Departments of Cardiology and Diagnostic Radiology, McGill University Health Centre, Montreal, QC, Canada
- KMID: 2541640
- DOI: http://doi.org/10.4250/jcvi.2022.0080
Abstract
- BACKGROUND
Cardiac magnetic resonance fingerprinting (cMRF) enables simultaneous mapping of myocardial T1 and T2 with very short acquisition times. Breathing maneuvers have been utilized as a vasoactive stress test to dynamically characterize myocardial tissue in vivo. We tested the feasibility of sequential, rapid cMRF acquisitions during breathing maneuvers to quantify myocardial T1 and T2 changes.
METHODS
We measured T1 and T2 values using conventional T1 and T2-mapping techniques (modified look locker inversion [MOLLI] and T2-prepared balanced-steady state free precession), and a 15 heartbeat (15-hb) and rapid 5-hb cMRF sequence in a phantom and in 9 healthy volunteers. The cMRF 5-hb sequence was also used to dynamically assess T1 and T2 changes over the course of a vasoactive combined breathing maneuver.
RESULTS
In healthy volunteers, the mean myocardial T1 of the different mapping methodologies were: MOLLI 1,224 ± 81 ms, cMRF 15-hb 1,359 ± 97 ms, and cMRF 5-hb 1,357 ± 76 ms. The mean myocardial T2 measured with the conventional mapping technique was 41.7 ± 6.7 ms, while for cMRF 15-hb 29.6 ± 5.8 ms and cMRF 5-hb 30.5 ± 5.8 ms. T2 was reduced with vasoconstriction (post-hyperventilation compared to a baseline resting state) (30.15 ± 1.53 ms vs. 27.99 ± 2.07 ms, p = 0.02), while T1 did not change with hyperventilation. During the vasodilatory breath-hold, no significant change of myocardial T1 and T2 was observed.
CONCLUSIONS
cMRF 5-hb enables simultaneous mapping of myocardial T1 and T2, and may be used to track dynamic changes of myocardial T1 and T2 during vasoactive combined breathing maneuvers.
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