Korean J Anesthesiol.  2023 Apr;76(2):89-98. 10.4097/kja.22654.

Mechanisms and implications in gene polymorphism mediated diverse reponses to sedatives, analgesics and muscle relaxants

• Sun Y
• Zhu H
• Esmaeili E
• Tang X
• Wu Z

• KMID: 2540998
• DOI: http://doi.org/10.4097/kja.22654

Abstract

Responses to sedatives, analgesics and muscle relaxants vary among patients under general anesthesia, which could be ascribed to the disparities of clinical characteristics and genetic factors of individuals. Accumulating researches have indicated that gene polymorphisms of the receptors, transporters and metabolizing enzymes associated with anesthetics play a considerable role in their efficacy. However, a systematically summarized study on the mechanisms of gene polymorphisms on pharmacodynamics and pharmacokinetics of anesthetics is still lacking. In this paper, the recent researches on pharmacogenomics of sedatives, analgesics and muscle relaxants are comprehensively reviewed, and the contributions and mechanisms of polymorphisms to the differences of individual efficacy of these drugs are discussed, so as to provide guidance for the formulation of a rational anesthesia regimen for patients with various genotypes.

Keyword

Analgesics; Gene polymorphism; Individual differences; Neuromuscular blocking agents; Pharmacogenomics; Sedatives