J Korean Diabetes.  2023 Mar;24(1):24-28. 10.4093/jkd.2023.24.1.24.

Diabetes and Periodontal Disease

Affiliations
  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

Abstract

Diabetes and periodontitis are chronic inflammatory diseases and have a bidirectional relationship. Periodontitis is more prevalent and more severe in diabetic persons than in nondiabetic persons, and diabetes plays a crucial role in the pathogenesis of periodontitis. Also, periodontitis has shown elevated risk for hyperglycemia and insulin resistance. Thus, mutual management of the two conditions might be necessary. Periodontal therapy is effective in persons with diabetes and is associated with reduction of HbA1c. The present study reviews the mechanistic link between diabetes and periodontitis and the effects of periodontal treatment and can aid in educational planning to prevent periodontitis of diabetic persons.

Keyword

Diabetes complications; Diabetes mellitus; Periodontitis

Reference

1.Meyle J., Chapple I. Molecular aspects of the pathogenesis of periodontitis. Periodontol 2000. 2015. 69:7–17.
2.Gemmell E., Marshall RI., Seymour GJ. Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease. Periodontol 2000. 1997. 14:112–43.
3.Kumar M., Mishra L., Mohanty R., Nayak R. Diabetes and gum disease: the diabolic duo. Diabetes Metab Syndr. 2014. 8:255–8.
4.Mealey BL., Oates TW; American Academy of Periodontology. Diabetes mellitus and periodontal diseases. J Periodontol. 2006. 77:1289–303.
5.Seppälä B., Ainamo J. A site-by-site follow-up study on the effect of controlled versus poorly controlled insulin-de-pendent diabetes mellitus. J Clin Periodontol. 1994. 21:161–5.
6.Löe H. Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care. 1993. 16:329–34.
7.Taylor GW., Burt BA., Becker MP., Genco RJ., Shlossman M., Knowler WC, et al. Non-insulin dependent diabetes mellitus and alveolar bone loss progression over 2 years. J Periodontol. 1998. 69:76–83.
8.Collison KS., Parhar RS., Saleh SS., Meyer BF., Kwaasi AA., Hammami MM, et al. RAGE-mediated neutrophil dysfunction is evoked by advanced glycation end products (AGEs). J Leukoc Biol. 2002. 71:433–44.
9.Takeda M., Ojima M., Yoshioka H., Inaba H., Kogo M., Shizukuishi S, et al. Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients. J Periodontol. 2006. 77:15–20.
10.Lalla E., Lamster IB., Stern DM., Schmidt AM. Receptor for advanced glycation end products, inflammation, and accelerated periodontal disease in diabetes: mechanisms and insights into therapeutic modalities. Ann Periodontol. 2001. 6:113–8.
11.Chang PC., Chien LY., Yeo JF., Wang YP., Chung MC., Chong LY, et al. Progression of periodontal destruction and the roles of advanced glycation end products in exper-imental diabetes. J Periodontol. 2013. 84:379–88.
12.Janket SJ., Wightman A., Baird AE., Van Dyke TE., Jones JA. Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies. J Dent Res. 2005. 84:1154–9.
13.Noack B., Genco RJ., Trevisan M., Grossi S., Zambon JJ., De Nardin E. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol. 2001. 72:1221–7.
14.Nishimura F., Iwamoto Y., Mineshiba J., Shimizu A., Soga Y., Murayama Y. Periodontal disease and diabetes mellitus: the role of tumor necrosis factor-alpha in a 2-way relation-ship. J Periodontol. 2003. 74:97–102.
15.Sanz M., Ceriello A., Buysschaert M., Chapple I., Demmer RT., Graziani F, et al. Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. Diabetes Res Clin Pract. 2018. 137:231–41.
16.Sharma P., Dietrich T., Ferro CJ., Cockwell P., Chapple IL. Association between periodontitis and mortality in stages 3-5 chronic kidney disease: NHANES III and linked mortality study. J Clin Periodontol. 2016. 43:104–13.
17.Tonetti MS., Van Dyke TE; working group 1 of the joint EFP/AAP workshop*. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAPWorkshop on Periodontitis and Systemic Diseases. J Periodontol. 2013. 84(Suppl 4S):S24–9.
18.Madianos PN., Koromantzos PA. An update of the evidence on the potential impact of periodontal therapy on diabetes outcomes. J Clin Periodontol. 2018. 45:188–95.
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