J Dent Hyg Sci.  2018 Jun;18(3):137-146. 10.17135/jdhs.2018.18.3.137.

Effects of Periodontal Treatment on Glycated Hemoglobin A Levels in Patients with Type 2 Diabetes: A Meta-Analysis of Randomized Clinical Trials

• Son SH
• Lee ES

• KMID: 2415278
• DOI: http://doi.org/10.17135/jdhs.2018.18.3.137

Abstract

This systematic review aimed to investigate the effects of periodontal treatment on glycated hemoglobin A (HbA1c) levels in patients with type 2 diabetes who develop periodontal disease. The search of the MEDLINE, Embase, CINAHL, and Cochrane Library databases was completed on April 8, 2018. The study design was based on randomized clinical trials. Scaling and root planing was performed for the test group, whereas no periodontal treatment or simple oral training was performed for the control group. The main outcome variable was the change in HbA1c levels. We used the Review Manager statistical analysis software for the quantitative analysis of selected documents. Meta-analysis was performed using the inverse variance estimation method of the fixed-effect model to estimate the effects of periodontal treatment on HbA1c levels in patients with type 2 diabetes. A total of 1,011 documents were searched using search strategies, and 10 documents were included in the meta-analysis. The meta-analysis of the selected literature showed that periodontal treatment significantly reduced the HbA1c levels in patients with type 2 diabetes who develop periodontal disease (mean difference, −0.34; 95% confidence interval, −0.43 to −0.26; p<0.001). This study aimed to investigate the effects of periodontal treatment on HbA1c levels, which can be used as a basis for the increasing management of diabetic complications. To improve the quality of life and reduce the burden of medical expenses for patients with diabetes, periodontal disease management through nonsurgical periodontal treatment, such as scaling and root planing, is necessary.

Keyword

Dental scaling; Glycated hemoglobin A; Meta-analysis; Periodontal diseases; Type 2 diabetes mellitus

MeSH Terms

Dental Scaling
Diabetes Complications
Diabetes Mellitus, Type 2
Hemoglobin A, Glycosylated*
Humans
Methods
Periodontal Diseases
Quality of Life
Root Planing