Korean J Psychosom Med.  2022 Dec;30(2):165-171. 10.22722/KJPM.2022.30.2.165.

The Effect of Second-Generation Antipsychotics Administration for 1-Year on the Platelet Activities in Patients With Schizophrenia: Retrospective Study

• Oh YS
• Lee JW
• Oh HS
• Kim SJ
• Im WY
• Lee NH
• Kim JW

• KMID: 2538662
• DOI: http://doi.org/10.22722/KJPM.2022.30.2.165

Abstract

Objectives
：This study was conducted to investigate the effect of 1-year administration of second-generation antipsychotics (SGAs) on the platelet activity in patients with schizophrenia through a retrospective review of the medical records.
Methods
：The mean platelet component (MPC) value was used as an index of the platelet activity. The included subjects (N=24) were the patients who were confirmed to have taken SGAs continuously for one year after the first MPC measurement had been performed. The change of MPC was verified through a paired sample t-test.
Results
：The result revealed that the mean MPC value was significantly decreased from 26.5±1.4 g/dL to 25.6±1.8 g/dL after 1-year administration of SGAs from the time of the first MPC measurement.
Conclusions
：This study suggests that 1-year administration of SGAs may be related with increased platelet activity, and that close monitoring for risks such as cerebrovascular/cardiovascular or thromboembolic diseases may be necessary during SGAs treatment in clinical practice.

Keyword

Second-generation antipsychotics; Mean platelet component; Platelet activity; Schizophrenia; Cerebrovascular/cardiovascular diseases