Korean J Psychosom Med.  2020 Jun;28(1):36-41. 10.22722/KJPM.2020.28.1.36.

A Retrospective Study on the Effect of 1-Year Clozapine Administration on Platelet Activity in Patients with Schizophrenia or Schizoaffective Disorder

• Jang E
• Lee JW
• Kim SJ
• Oh HS
• Im WY
• Lee NH
• Kim JW

• KMID: 2503768
• DOI: http://doi.org/10.22722/KJPM.2020.28.1.36

Abstract

Objectives
：Clozapine has been known to increase the possibility of developing cardio/cerebrovascular diseases, and the platelet activation has been deemed to be related to the occurrence of them. In author’s previous study, we observed the increase of platelet activity with short-term clozapine administration. This study was conducted, as a follow-up study, to investigate the effect of clozapine on the platelet activity when administered continuously for long-term period of time of 1 year.
Methods
：The medical records of the patients with schizophrenia or schizoaffective disorder who were treated with clozapine for 1 year were retrospectively reviewed. The degree of platelet activation was assessed by measuring the mean platelet component.
Results
：Total of 24 patients were enrolled. 9 of them (37.5%) were male and 15 of them (62.5%) were female. In the Wilcoxon sign-ranks test, no significant change was observed between the mean platelet factor values at the beginning and at the end of one year.
Conclusions
：No significant changes of mean platelet activity were observed after continued administration of clozapine for 1 year. Considering the author’s previous findings that observed a prominent decrease of mean platelet component after short-term clozapine administration, the result of this study suggests the possibility that the activity of the platelet may change depending on the duration of the clozapine administration.

Keyword

Clozapine; Mean platelet component; Platelet activation; Metabolic side effects; Thromboembolic disease