Lab Med Online.  2022 Oct;12(4):304-309. 10.47429/lmo.2022.12.4.304.

Changes in the Serum Levels of Parathyroid Hormone and Bone Metabolites in Two Serial Samples with Different Vitamin D Status

• Park PW
• Park IK

• KMID: 2538619
• DOI: http://doi.org/10.47429/lmo.2022.12.4.304

Abstract

Background
Vitamin D increases serum calcium levels by promoting calcium absorption in intestines. Vitamin D deficiency raises the serum levels of parathyroid hormone (PTH) and bone metabolites. Generally, vitamin D status is classified into three groups named deficiency, insufficiency, and adequacy by its level. Deficient level affect bone health, while insufficient level influence the soft tissue disease. We observed the effect of changes in vitamin D status on serum PTH and bone metabolite levels using two different samples taken from the same individual.
Methods
Serum PTH, osteocalcin (OST), carboxy-terminal telopeptide of type I collagen (CTX), and 25(OH) vitamin D was evaluated in 857 patients. The levels were measured again after six months or later. The changes in the levels of each biomarker based on the change in vitamin D status in two serial samples were estimated through paired t-test. Vitamin D status was classified into three groups: deficiency (<10 ng/mL), insufficiency (10-30 ng/mL), and adequacy (>30 ng/mL).
Results
No statistically significant changes in PTH, OST and, CTX levels were found in the group without altered vitamin D status. The same biomarkers were decreased in the group where vitamin D status improved from deficiency or insufficiency to adequacy.
Conclusions
Maintaining vitamin D at the adequate level was not only helpful in preventing soft tissue disease but also seemed to promote bone health as indicated by the change in PTH and bone metabolites levels during the transition of vitamin D status from both deficient and insufficient states to the adequate state.

Keyword

25(OH) vitamin D; Parathyroid hormone; Osteocalcin; Carboxy-terminal telopeptide of type I collagen

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