J Korean Dent Sci.  2022 Dec;15(2):121-131. 10.5856/JKDS.2022.15.2.121.

Current Opinion in Molecular Pathology of Ameloblastoma: A Literature Review

• Lee D
• Li S
• Jung H

• KMID: 2538556
• DOI: http://doi.org/10.5856/JKDS.2022.15.2.121

Abstract

Ameloblastoma is the most representative epithelial odontogenic tumor in the craniofacial region. Through several studies on Ameloblastoma that have been conducted so far, we have been able to get closer to the reality of Ameloblastoma. However, groundbreaking insight into the pathophysiology of Ameloblastoma has not yet been provided. This review assessed three aspects of five recently published papers on Ameloblastoma: cancer stem cells, calcium signaling, and tumor microenvironment, and compared them with previous studies on tumor physiology, including cancer. In addition, the characteristics of Ameloblastoma revealed by the experimental methods presented in the currently published five papers provide the possibility of Ameloblastoma as a study model in general tumor or cancer studies. Furthermore, the mechanisms of action of the chemicals identified in the studies support their potential as candidates for the second-line treatment of Ameloblastoma.

Keyword

Ameloblastoma; Calcium signaling; Cancer stem cell; Collagen; Tumor microenvironment; Wnt signaling pathway