Transl Clin Pharmacol.  2022 Mar;30(1):49-56. 10.12793/tcp.2022.30.e3.

Evaluation of food effects on the pharmacokinetics of Pelargonium sidoides and Coptis with each bioactive compound berberine and epicatechin after a single oral dose of an expectorant and antitussive agent UI026 in healthy subjects

• Park Y
• Jung W
• Yang E
• Nam KY
• Bong WR
• Kim J
• Kim KY
• Lee S
• Cho JY
• Hong JH
• Kim J

• KMID: 2538273
• DOI: http://doi.org/10.12793/tcp.2022.30.e3

Abstract

UI026 is an expectorant and antitussive agent which is a new combination of Pelargonium sidoides extract andCoptis extract. The bioactive compounds of Pelargonium sidoides and Coptis extracts were identified as epicatechin and berberine, respectively. This study evaluated the effect of food on the pharmacokinetics (PKs) and safety of UI026. A randomized, openlabel, single-dose, 2-treatment, parallel study in 12 healthy male subjects was performed. Subjects received a single oral dose of UI026 (27 mL of syrup) under a fed or fasted condition according to their randomly assigned treatment. Blood samples for the PK analysis were obtained up to 24 hours post-dose for berberine and 12 hours post-dose for epicatechin. The PK parameters were calculated by non-compartmental analysis. In the fed condition, the mean maximum plasma concentration (C _max ) and mean area under the plasma concentrationtime curve from time zero to the last observed time point (AUC _last ) for berberine were approximately 33% and 67% lower, respectively, compared with the fasted condition, both showing statistically significant difference. For epicatechin, the mean C _max and mean AUC _last were about 29% and 45% lower, respectively, compared to the fasting condition, neither of which showed a statistically significant difference. There were no drug-related adverse events. This finding suggests that food affects the systemic exposure and bioavailability of berberine and epicatechin.

Keyword

Pharmacokinetics; Bioavailability; Berberine; Epicatechin; Herbal Medicine