- Evaluation of Vancomycin TDM Strategies: Prediction and Prevention of Kidney Injuries Based on Vancomycin TDM Results
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Kim B, Hwang S, Heo E, Kim Hs, Jung J, Kim ES, Kim HB, Lee K, Park JS, Song J, Lee JH, Chung JY, Song KH, Yoon S
- KMID: 2541546
- J Korean Med Sci.
- 2023 Apr;38(14):e101.
- doi: 10.3346/jkms.2023.38.e101
The current guidelines for therapeutic drug monitoring (TDM) of vancomycin suggest a target 24-hour area under the curve (AUC 0-24 ) of 400 to 600 mg*h/L for serious methicillinresistant Staphylococcus... -
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- Population Pharmacokinetics and Monte Carlo Simulation of Cefepime in Critically Ill Patients with Hospital-Acquired/ Ventilator-Associated Pneumonia
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Seo H, Kim YK, Park S, Kim Hi, Lee DH
- KMID: 2541529
- Infect Chemother.
- 2023 Mar;55(1):29-41.
- doi: 10.3947/ic.2022.0087
Background: This study aimed to investigate the population pharmacokinetics (PK) profile and determine the optimal dosage regimen of cefepime in critically ill adult patients with hospital-acquired pneumonia (HAP) or ventilatorassociated... -
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- Predicting the systemic exposure and lung concentration of nafamostat using physiologically-based pharmacokinetic modeling
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Jeong HC, Chae YJ, Shin KH
- KMID: 2538882
- Transl Clin Pharmacol.
- 2022 Dec;30(4):201-211.
- doi: 10.12793/tcp.2022.30.e20
Nafamostat has been actively studied for its neuroprotective activity and effect on various indications, such as coronavirus disease 2019 (COVID-19). Nafamostat has low water solubility at a specific pH and... -
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- Prevalence and prediction of augmented renal clearance in the neurocritical care population
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Cook AM, Li D, Nestor MA, Bastin MLT
- KMID: 2538766
- J Neurocrit Care.
- 2022 Dec;15(2):96-103.
- doi: 10.18700/jnc.220061
Background: Augmented renal clearance (ARC; creatinine clearance [CrCl] >130 mL/min/1.73 m2) is prevalent in patients with neurological injuries and may influence their exposure to important pharmacological therapies. Little is known... -
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- Effects of Dextran Sulfate Sodium-Induced Ulcerative Colitis on the Disposition of Tofacitinib in Rats
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Bae SH, Kim HS, Choi HG, Chang SY, Kim SH
- KMID: 2534700
- Biomol Ther.
- 2022 Nov;30(6):510-519.
- doi: 10.4062/biomolther.2022.049
Tofacitinib, a Janus kinase 1 and 3 inhibitor, is mainly metabolized by CYP3A1/2 and CYP2C11 in the liver. The drug has been approved for the chronic treatment of severe ulcerative... -
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- A randomized, open-label, single-dose, two-way crossover study to assess the pharmacokinetics between two tablets of fixed-dose combination formulation with raloxifene and cholecalciferol and concomitant administration of each agents in healthy male volunteers
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Lee HW, Kang WY, Gwon MR, Choi EJ, Kim EH, Cho K, Lee B, Seong SJ, Yoon YR
- KMID: 2538875
- Transl Clin Pharmacol.
- 2022 Sep;30(3):136-144.
- doi: 10.12793/tcp.2022.30.e13
A new fixed-dose combination (FDC) formulation of raloxifene 60 mg and cholecalciferol 800 IU was developed to improve the medication compliance and overall efficacy of raloxifene treatment in postmenopausal osteoporosis... -
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- Effects of feed intake and water hardness on fluralaner pharmacokinetics in layer chickens
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Sari AB, Gunes Y, Anlas C, Alkan FU, Guncum E, Ustuner O, Bakirel T
- KMID: 2533381
- J Vet Sci.
- 2022 Sep;23(5):e64.
- doi: 10.4142/jvs.22048
Background: Fluralaner is a novel drug belonging to the isoxazoline class that acts on external parasites of domestic animals. It is used systemically via drinking water, especially against red poultry... -
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- Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model
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Park SJ, Lee EJ, Seol A, Park S, Ham J, Yim GW, Shim SH, Lim W, Chang SJ, Song G, Park JW, Kim HS, on behalf of the Korean Rotational Intraperitoneal pressurized Aerosol chemotherapy (KoRIA) Trial Group
- KMID: 2537904
- J Gynecol Oncol.
- 2022 Sep;33(5):e56.
- doi: 10.3802/jgo.2022.33.e56
Objective We used paclitaxel and cisplatin, known to be effective in intraperitoneal chemotherapy, in a novel prototype of rotational intraperitoneal pressurized aerosol chemotherapy (RIPAC) and evaluated the pharmacokinetics, tissue concentrations, and... -
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- Comparative pharmacokinetics between two tablets of tramadol 37.5 mg/acetaminophen 325 mg and one tablet of tramadol 75 mg/acetaminophen 650 mg for extended-release fixed-dose combination
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Kim HC, Yoon DY, Lee S, Jang IJ, Hong JH, Kim J
- KMID: 2538872
- Transl Clin Pharmacol.
- 2022 Jun;30(2):112-119.
- doi: 10.12793/tcp.2022.30.e12
An extended-release (ER) fixed-dose combination (FDC) of tramadol 37.5 mg/acetaminophen 325 mg was developed due to the demand for varying dosages. This study aimed to evaluate the pharmacokinetics (PKs) for... -
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- Physiologically-based pharmacokinetic modeling of nafamostat to support dose selection for treatment of pediatric patients with COVID-19
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Cho YS, Shin JG
- KMID: 2538269
- Transl Clin Pharmacol.
- 2022 Mar;30(1):24-36.
- doi: 10.12793/tcp.2022.30.e4
Pediatric patients with coronavirus disease 2019 (COVID-19) are increasing, and severe cases such as multisystem inflammatory syndrome are being reported. Nafamostat, a repurposing drug, is currently being explored for the... -
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- Evaluation of food effects on the pharmacokinetics of Pelargonium sidoides and Coptis with each bioactive compound berberine and epicatechin after a single oral dose of an expectorant and antitussive agent UI026 in healthy subjects
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Park Y, Jung W, Yang E, Nam KY, Bong WR, Kim J, Kim KY, Lee S, Cho JY, Hong JH, Kim J
- KMID: 2538273
- Transl Clin Pharmacol.
- 2022 Mar;30(1):49-56.
- doi: 10.12793/tcp.2022.30.e3
UI026 is an expectorant and antitussive agent which is a new combination of Pelargonium sidoides extract andCoptis extract. The bioactive compounds of Pelargonium sidoides and Coptis extracts were identified as... -
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- Remimazolam: pharmacological characteristics and clinical applications in anesthesiology
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Kim KM
- KMID: 2526522
- Anesth Pain Med.
- 2022 Jan;17(1):1-11.
- doi: 10.17085/apm.21115
A novel ultra-short-acting benzodiazepine (BDZ), remimazolam (CNS 7056), has been designed by ‘soft drug’ development to achieve a better sedative profile than that of the current drugs. Notably, the esterase... -
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- An experience on the model-based evaluation of pharmacokinetic drug-drug interaction for a long half-life drug
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Hong Y, Jeon S, Choi S, Han S, Park M, Han S
- KMID: 2521480
- Korean J Physiol Pharmacol.
- 2021 Nov;25(6):545-553.
- doi: 10.4196/kjpp.2021.25.6.545
Fixed-dose combinations development requires pharmacokinetic drugdrug interaction (DDI) studies between active ingredients. For some drugs, pharmacokinetic properties such as long half-life or delayed distribution, make it difficult to conduct such... -
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- Pharmacokinetic properties and bioequivalence of gefitinib 250 mg in healthy Korean male subjects
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Moon SJ, Kim Y, Jeon JY, Park SJ, Kwak YG, Kim MG
- KMID: 2525614
- Transl Clin Pharmacol.
- 2021 Sep;29(3):171-179.
- doi: 10.12793/tcp.2021.29.e17
Gefitinib is an anti-cancer drug used to treat non-small cell lung cancer. The objective of this study was to compare the pharmacokinetics and evaluate the bioequivalence of 2 orally administered... -
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- Comparison of the pharmacokinetics and pharmacodynamics of YH4808 in healthy subjects for defining an appropriate dosing regimen
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Yoon S, Oh E, Park MS, Jang SB, Byun HM, Park H, Kim H, Kim CO
- KMID: 2525612
- Transl Clin Pharmacol.
- 2021 Sep;29(3):150-159.
- doi: 10.12793/tcp.2021.29.e15
YH4808 is a novel potassium-competitive acid blocker developed for gastric acid-related disorders. Previous studies indicate its potential to improve symptoms of gastric acid-related disorders. The current study was aimed to... -
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- Ustekinumab pharmacokinetics after subcutaneous administration in swine model
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Grabowski T, Burmańczuk A, Derlacz R, Stefaniak T, Rząsa A, Borkowski J
- KMID: 2520761
- J Vet Sci.
- 2021 Sep;22(5):e47.
- doi: 10.4142/jvs.2021.22.e47
Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of... -
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- Biodistribution of Exosomes and Engineering Strategies for Targeted Delivery of Therapeutic Exosomes
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Choi H, Choi Y, Yim HY, Mirzaaghasi A, Yoo JK, Choi C
- KMID: 2519208
- Tissue Eng Regen Med.
- 2021 Aug;18(4):499-511.
- doi: 10.1007/s13770-021-00361-0
Exosomes are cell-secreted nano-sized vesicles which deliver diverse biological molecules for intercellular communication. Due to their therapeutic potential, exosomes have been engineered in numerous ways for efficient delivery of active... -
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- Interpretation of volume kinetics in terms of pharmacokinetic principles
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Choi BM
- KMID: 2517138
- Korean J Anesthesiol.
- 2021 Jun;74(3):204-217.
- doi: 10.4097/kja.21085
Volume kinetics is the pharmacokinetics of infusion fluids and describes the distribution and elimination of infused volume. Generally, pharmacokinetic parameters can be estimated by measuring the concentration of a drug.... -
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- Comparison of pharmacokinetics and safety characteristics between two olopatadine hydrochloride 5 mg tablet formulations in healthy Korean subjects
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Kim JH, Lee M, Kim N, Oh TY, Nam SK, Choi YS, Kwon IS, Jung JG, Hong JH
- KMID: 2525601
- Transl Clin Pharmacol.
- 2021 Mar;29(1):65-72.
- doi: 10.12793/tcp.2021.29.e6
Histamine acts by binding to four histamine receptors (H1 to H4), of which the H1 is known to participate in dilate blood vessels, bronchoconstriction, and pruritus. Olopatadine hydrochloride blocks the... -
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- Pharmacokinetic comparison between a fixed-dose combination of fimasartan/amlodipine/ hydrochlorothiazide 60/10/25 mg and a corresponding loose combination of fimasartan/amlodipine 60/25 mg and hydrochlorothiazide 25 mg in healthy subjects
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Jung J, Lee S, Oh J, Lee S, Jang IJ, Lee D, Yu KS
- KMID: 2525603
- Transl Clin Pharmacol.
- 2021 Mar;29(1):53--64.
- doi: 10.12793/tcp.2021.29.e5
For the treatment of hypertension, fixed-dose combinations (FDCs) of antihypertensive drugs can provide complementary benefits from improved compliance and cost-effectiveness compared with loose combinations of corresponding drugs. A new FDC... -
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