Skip Navigation
Skip to contents
Results by Year

View Wide

Filter

ARTICLE TYPE

more+
SELECT FILTER
 
Close

PUBLICATION DATE

251 results
Display

Evaluation of Vancomycin TDM Strategies: Prediction and Prevention of Kidney Injuries Based on Vancomycin TDM Results

Kim B, Hwang S, Heo E, Kim Hs, Jung J, Kim ES, Kim HB, Lee K, Park JS, Song J, Lee JH, Chung JY, Song KH, Yoon S

The current guidelines for therapeutic drug monitoring (TDM) of vancomycin suggest a target 24-hour area under the curve (AUC 0-24 ) of 400 to 600 mg*h/L for serious methicillinresistant Staphylococcus...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Population Pharmacokinetics and Monte Carlo Simulation of Cefepime in Critically Ill Patients with Hospital-Acquired/ Ventilator-Associated Pneumonia

Seo H, Kim YK, Park S, Kim Hi, Lee DH

Background: This study aimed to investigate the population pharmacokinetics (PK) profile and determine the optimal dosage regimen of cefepime in critically ill adult patients with hospital-acquired pneumonia (HAP) or ventilatorassociated...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Predicting the systemic exposure and lung concentration of nafamostat using physiologically-based pharmacokinetic modeling

Jeong HC, Chae YJ, Shin KH

Nafamostat has been actively studied for its neuroprotective activity and effect on various indications, such as coronavirus disease 2019 (COVID-19). Nafamostat has low water solubility at a specific pH and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Prevalence and prediction of augmented renal clearance in the neurocritical care population

Cook AM, Li D, Nestor MA, Bastin MLT

Background: Augmented renal clearance (ARC; creatinine clearance [CrCl] >130 mL/min/1.73 m2) is prevalent in patients with neurological injuries and may influence their exposure to important pharmacological therapies. Little is known...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effects of Dextran Sulfate Sodium-Induced Ulcerative Colitis on the Disposition of Tofacitinib in Rats

Bae SH, Kim HS, Choi HG, Chang SY, Kim SH

Tofacitinib, a Janus kinase 1 and 3 inhibitor, is mainly metabolized by CYP3A1/2 and CYP2C11 in the liver. The drug has been approved for the chronic treatment of severe ulcerative...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
A randomized, open-label, single-dose, two-way crossover study to assess the pharmacokinetics between two tablets of fixed-dose combination formulation with raloxifene and cholecalciferol and concomitant administration of each agents in healthy male volunteers

Lee HW, Kang WY, Gwon MR, Choi EJ, Kim EH, Cho K, Lee B, Seong SJ, Yoon YR

A new fixed-dose combination (FDC) formulation of raloxifene 60 mg and cholecalciferol 800 IU was developed to improve the medication compliance and overall efficacy of raloxifene treatment in postmenopausal osteoporosis...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effects of feed intake and water hardness on fluralaner pharmacokinetics in layer chickens

Sari AB, Gunes Y, Anlas C, Alkan FU, Guncum E, Ustuner O, Bakirel T

Background: Fluralaner is a novel drug belonging to the isoxazoline class that acts on external parasites of domestic animals. It is used systemically via drinking water, especially against red poultry...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model

Park SJ, Lee EJ, Seol A, Park S, Ham J, Yim GW, Shim SH, Lim W, Chang SJ, Song G, Park JW, Kim HS, on behalf of the Korean Rotational Intraperitoneal pressurized Aerosol chemotherapy (KoRIA) Trial Group

Objective We used paclitaxel and cisplatin, known to be effective in intraperitoneal chemotherapy, in a novel prototype of rotational intraperitoneal pressurized aerosol chemotherapy (RIPAC) and evaluated the pharmacokinetics, tissue concentrations, and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Comparative pharmacokinetics between two tablets of tramadol 37.5 mg/acetaminophen 325 mg and one tablet of tramadol 75 mg/acetaminophen 650 mg for extended-release fixed-dose combination

Kim HC, Yoon DY, Lee S, Jang IJ, Hong JH, Kim J

An extended-release (ER) fixed-dose combination (FDC) of tramadol 37.5 mg/acetaminophen 325 mg was developed due to the demand for varying dosages. This study aimed to evaluate the pharmacokinetics (PKs) for...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Physiologically-based pharmacokinetic modeling of nafamostat to support dose selection for treatment of pediatric patients with COVID-19

Cho YS, Shin JG

Pediatric patients with coronavirus disease 2019 (COVID-19) are increasing, and severe cases such as multisystem inflammatory syndrome are being reported. Nafamostat, a repurposing drug, is currently being explored for the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Evaluation of food effects on the pharmacokinetics of Pelargonium sidoides and Coptis with each bioactive compound berberine and epicatechin after a single oral dose of an expectorant and antitussive agent UI026 in healthy subjects

Park Y, Jung W, Yang E, Nam KY, Bong WR, Kim J, Kim KY, Lee S, Cho JY, Hong JH, Kim J

UI026 is an expectorant and antitussive agent which is a new combination of Pelargonium sidoides extract andCoptis extract. The bioactive compounds of Pelargonium sidoides and Coptis extracts were identified as...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Remimazolam: pharmacological characteristics and clinical applications in anesthesiology

Kim KM

A novel ultra-short-acting benzodiazepine (BDZ), remimazolam (CNS 7056), has been designed by ‘soft drug’ development to achieve a better sedative profile than that of the current drugs. Notably, the esterase...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
An experience on the model-based evaluation of pharmacokinetic drug-drug interaction for a long half-life drug

Hong Y, Jeon S, Choi S, Han S, Park M, Han S

Fixed-dose combinations development requires pharmacokinetic drugdrug interaction (DDI) studies between active ingredients. For some drugs, pharmacokinetic properties such as long half-life or delayed distribution, make it difficult to conduct such...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Pharmacokinetic properties and bioequivalence of gefitinib 250 mg in healthy Korean male subjects

Moon SJ, Kim Y, Jeon JY, Park SJ, Kwak YG, Kim MG

Gefitinib is an anti-cancer drug used to treat non-small cell lung cancer. The objective of this study was to compare the pharmacokinetics and evaluate the bioequivalence of 2 orally administered...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Comparison of the pharmacokinetics and pharmacodynamics of YH4808 in healthy subjects for defining an appropriate dosing regimen

Yoon S, Oh E, Park MS, Jang SB, Byun HM, Park H, Kim H, Kim CO

YH4808 is a novel potassium-competitive acid blocker developed for gastric acid-related disorders. Previous studies indicate its potential to improve symptoms of gastric acid-related disorders. The current study was aimed to...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Ustekinumab pharmacokinetics after subcutaneous administration in swine model

Grabowski T, Burmańczuk A, Derlacz R, Stefaniak T, Rząsa A, Borkowski J

Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Biodistribution of Exosomes and Engineering Strategies for Targeted Delivery of Therapeutic Exosomes

Choi H, Choi Y, Yim HY, Mirzaaghasi A, Yoo JK, Choi C

Exosomes are cell-secreted nano-sized vesicles which deliver diverse biological molecules for intercellular communication. Due to their therapeutic potential, exosomes have been engineered in numerous ways for efficient delivery of active...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Interpretation of volume kinetics in terms of pharmacokinetic principles

Choi BM

Volume kinetics is the pharmacokinetics of infusion fluids and describes the distribution and elimination of infused volume. Generally, pharmacokinetic parameters can be estimated by measuring the concentration of a drug....
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Comparison of pharmacokinetics and safety characteristics between two olopatadine hydrochloride 5 mg tablet formulations in healthy Korean subjects

Kim JH, Lee M, Kim N, Oh TY, Nam SK, Choi YS, Kwon IS, Jung JG, Hong JH

Histamine acts by binding to four histamine receptors (H1 to H4), of which the H1 is known to participate in dilate blood vessels, bronchoconstriction, and pruritus. Olopatadine hydrochloride blocks the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Pharmacokinetic comparison between a fixed-dose combination of fimasartan/amlodipine/ hydrochlorothiazide 60/10/25 mg and a corresponding loose combination of fimasartan/amlodipine 60/25 mg and hydrochlorothiazide 25 mg in healthy subjects

Jung J, Lee S, Oh J, Lee S, Jang IJ, Lee D, Yu KS

For the treatment of hypertension, fixed-dose combinations (FDCs) of antihypertensive drugs can provide complementary benefits from improved compliance and cost-effectiveness compared with loose combinations of corresponding drugs. A new FDC...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close

Go to Top

Copyright © 2023 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr