Blood Res.  2022 Dec;57(4):278-281. 10.5045/br.2022.2022134.

Detection of NUP214-ABL1 translocation using BCR-ABL1 dual color FISH probes in T-cell acute lymphoblastic leukemia–an illustrative report and review of literature

• Virk H
• Sreedharanunni S
• Palla S
• Rastogi P
• Rathore S
• Anshu A
• Trehan A

• KMID: 2537551
• DOI: http://doi.org/10.5045/br.2022.2022134

Figure

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  Fig. 1 (A) FISH using BCR-ABL1 dual-color dual-fusion probe showing two green signals (normal BCR gene) and multiple orange signals (3–50 copies), indicating amplification of the ABL1 gene; (B, C) FISH using ABL1 break-apart probe showing one fusion (normal ABL1 gene) and multiple orange signals, indicating amplification of the 3′ region of the ABL1 gene along with deletion of the 5′ region of the ABL1 gene; (D, E) FISH using NUP214 break-apart probe showing one fusion (normal NUP214 gene), one green (normal 3′ region of the other NUP214 allele), and multiple orange signals, indicating amplification of the 5′ region of the NUP214 gene. Abbreviation: FISH, fluorescent in-situ hybridization.

Reference

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