J Cancer Prev.  2017 Jun;22(2):74-81. 10.15430/JCP.2017.22.2.74.

Genomic Profiling of Chronic Myelogenous Leukemia: Basic and Clinical Approach

Affiliations
  • 1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. movafagh.a@sbmu.ac.ir
  • 2Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • 3Department of Social Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • 4Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Chronic myeloid leukemia (CML) is a hematological stem cell cancer driven by BCR-ABL1 fusion protein. We review the previous and recent evidence on the significance of CML in diagnostic and clinic management. The technical monitoring of BCR-ABL1 with quantitative real time-PCR has been used in assessing patient outcome. The cytogenetic mark of CML is Philadelphia chromosome, that is formed by reciprocal chromosomal translocations between human chromosome 9 and 22, t(9:22) (q³â´:q¹¹). It makes a BCR-ABL1 fusion protein with an anomaly tyrosine kinase activity that promotes the characteristic proliferation of progenitor cells in CML and acute lymphoblastic lymphoma. The targeting of BCR-ABL1 fusion kinase is the first novel paradigm of molecularly targeted curing.

Keyword

Chronic myeloid leukemia; Profile; Methods; BCR-ABL1

MeSH Terms

Chromosomes, Human
Cytogenetics
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Methods
Philadelphia Chromosome
Phosphotransferases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Stem Cells
Translocation, Genetic
Phosphotransferases
Protein-Tyrosine Kinases
Full Text Links
  • JCP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr