J Cancer Prev.
2017 Jun;22(2):74-81. 10.15430/JCP.2017.22.2.74.
Genomic Profiling of Chronic Myelogenous Leukemia: Basic and Clinical Approach
- Affiliations
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- 1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. movafagh.a@sbmu.ac.ir
- 2Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- 3Department of Social Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- 4Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- KMID: 2400770
- DOI: http://doi.org/10.15430/JCP.2017.22.2.74
Abstract
- Chronic myeloid leukemia (CML) is a hematological stem cell cancer driven by BCR-ABL1 fusion protein. We review the previous and recent evidence on the significance of CML in diagnostic and clinic management. The technical monitoring of BCR-ABL1 with quantitative real time-PCR has been used in assessing patient outcome. The cytogenetic mark of CML is Philadelphia chromosome, that is formed by reciprocal chromosomal translocations between human chromosome 9 and 22, t(9:22) (q³â´:q¹¹). It makes a BCR-ABL1 fusion protein with an anomaly tyrosine kinase activity that promotes the characteristic proliferation of progenitor cells in CML and acute lymphoblastic lymphoma. The targeting of BCR-ABL1 fusion kinase is the first novel paradigm of molecularly targeted curing.
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