Korean J Transplant.  2022 Nov;36(Supple 1):S348. 10.4285/ATW2022.F-4928.

Human leukocyte antigen DPB1 T-cell epitope analysis predicting for kidney transplantation outcome

• Kim SW
• Sohn S
• Hwang MS
• Park Y

• KMID: 2535575
• DOI: http://doi.org/10.4285/ATW2022.F-4928

Abstract

Background
The impact in the graft-versus-host vector of human leukocyte antigen (HLA)-DPB1 T-cell epitope (TCE) were studied in hematopoietic cell transplantation. HLA-DPB1 TCE-nonpermissive mismatching were associated with improved overall survival. The impact of HLA-DPB1 incompatibility on the outcomes of kidney transplantation is not fully understood. We investi-gated a potential effect of HLA-DPB1 TCE-nonpermissive mismatching on the short term outcome after kidney transplantation.
Methods
A cohort of 31 patients who received a kidney transplantation with availability of donor and recipient HLA-DPB1 high-resolution typing were analyzed retrospectively. HLA-DPB1 mismatches based on TCE were determined based on DPB1 TCE Algotithm 2.0 (https://www.ebi.ac.uk).
Results
Follow-up period varied from 7 to 183 days after transplantation. Normal creatinine level (1.19 mg/dL) was observed in 19 recipients (61.3%), and others creatinine level was under 2.5 mg/dL. HLA-DPB1 TCE-nonpermissive mismatching was deter-mined in six (19.4%). Whether desensitization due to ABO incompatible or not, possibility of abnormal creatinine level after trans-plantation in patients with HLA-DPB1 TCE-nonpermissive mismatching was higher than in patients with HLA-DPB1 TCE-permis-sive (odds ratio, 14.0; 95% confidence interval, 1.3–137.6).
Conclusions
Although a longer follow-up period and studies using a larger number of patients are needed, HLA-DPB1 TCE-non-permissive mismatching is one of factors that may affect the prognosis after kidney transplantation.