Infect Chemother.
2022 Sep;54(3):553-558. 10.3947/ic.2020.0089.
A Transient Effect of Convalescent Plasma Therapy in a Patient with Severe Covonavirus Disease 2019: A Case Report
- Affiliations
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- 1Division of Allergy and Pulmonary Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
- 2Division of Infectious Disease, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
- 3Division of Infectious Diseases, Department of Internal Medicine, Seongnam Citizens’ Medical Center, Seongnam, Korea
- 4Department of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
- 5Department of Laboratory Medicine and Genetics, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
- 6Division of Hematology and Oncology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
- 7Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea
- KMID: 2534171
- DOI: http://doi.org/10.3947/ic.2020.0089
Abstract
- A 65-year-old male patient with an end-stage renal disease was diagnosed with coronavirus disease 2019 (COVID-19) by reverse transcription polymerase chain reaction. The patient complained of cough, sputum, and respiratory distress that worsened three days ago. The patient required mechanical ventilation and extracorporeal mentrane oxygenation. On day 9, convalescent plasma collected from a 34-year old man who recovered from COVID-19 45 days ago was administered. The patient showed immediate clinical improvement. However, on day 14, the patient’s clinical course worsened again. On day 19 and day 24, vancomycin-resistant Enterococcus faecium bacteremia and methicillin-resistant Staphylococcus aureus pneumonia were found. After long-term supportive care, he slowly recovered. He was discharged on day 91 without any oxygen requirement. This case report suggests that convalescent plasma therapy might just provide a short-term relief and that persistent effort for critical care is necessary to save patients from severe COVID-19.
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