Ultrasonography.
2022 Oct;41(4):633-649. 10.14366/usg.21224.
Brain contrast-enhanced ultrasonography and elastography in infants
- Affiliations
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- 1Department of Radiology, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- 2Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA
- 3Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- 4Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- KMID: 2533842
- DOI: http://doi.org/10.14366/usg.21224
Abstract
- Advanced ultrasound techniques, including brain contrast-enhanced ultrasonography and elastography, are increasingly being explored to better understand infant brain health. While conventional brain ultrasonography provides a convenient, noninvasive means of assessing major intracranial pathologies, its value in revealing functional and physiologic insights into the brain lags behind advanced imaging techniques such as magnetic resonance imaging. In this regard, contrast-enhanced ultrasonography provides highly precise functional information on macrovascular and microvascular perfusion, while brain elastography offers information on brain stiffness that may be associated with relevant physiological factors of diagnostic, therapeutic, and/or prognostic utility. This review details the technical background, current understanding and utility, and future directions of these two emerging advanced ultrasound techniques for neonatal brain applications.
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