Med Lasers.  2021 Dec;10(4):195-200. 10.25289/ML.2021.10.4.195.

Proposed Mechanisms of Photobiomodulation (PBM) Mediated via the Stimulation of Mitochondrial Activity in Peripheral Nerve Injuries

• Choi JE

• KMID: 2533530
• DOI: http://doi.org/10.25289/ML.2021.10.4.195

Abstract

Evidence shows that nerve injury triggers mitochondrial dysfunction during axonal degeneration. Mitochondria play a pivotal role in axonal regeneration. Therefore, normalizing mitochondrial energy metabolism may represent an elective therapeutic strategy contributing to nerve recovery after damage. Photobiomodulation (PBM) induces a photo biological effect by stimulating mitochondrial activity. An increasing body of evidence demonstrates that PBM improves ATP generation and modulates many of the secondary mediators [reactive oxygen species (ROS), nitric oxide (NO), cyclic adenosine monophosphate (cAMP), and calcium ions (Ca²⁺ )], which in turn activate multiple pathways involved in axonal regeneration.

Keyword

Axon regeneration; Mitochondria; Photobioodulation; Peripheral nervous system