Med Lasers.  2020 Dec;9(2):172-178. 10.25289/ML.2020.9.2.172.

Effects of Photobiomodulation Therapy on Glycemic and Lipid Profiles In Vitro

• Hakami AR
• Alasmari S
• Makkawi M
• Mansour AA
• Ahmad I
• Shahrani MA
• Alkhathami A
• Dera AA
• Tedla JS
• Almane S
• Abudahish A
• AbuHadhyah J
• Alshehri M
• Mansour HA
• Saad M

• KMID: 2533484
• DOI: http://doi.org/10.25289/ML.2020.9.2.172

Abstract

Background and Objectives
This study aimed at examining the effects of photobiomodulation therapy (PBMT) on glucose, cholesterol, triglycerides, and low- and high-density lipoprotein (LDL and HDL, respectively) levels in vitro.
Materials and Methods
A total of 38 serum samples collected in plain (n=10) and heparinized tubes (n=28) were subjected to PBMT at 60 Joules (J)/cm² for 2 min at 810 nm. The glucose and lipid profiles, cholesterol, triglycerides, LDL, and HDL of each sample was measured before and after PBMT.
Results
A statistically significant increase in glucose levels was observed in the PBMT-sera in 8 out of 10 samples in plain tubes. However, only two samples that were prepared in heparinized tubes showed an increase in glucose levels. The remaining heparinized samples that were exposed to PBMT presented lower glucose values. The treated sera exhibited a fluctuation in the lipid profiles after PBMT. However, high cholesterol levels were evident following PBMT. Similar trends with HDL and LDL in heparinized tubes were evident.
Conclusion
Together, the findings suggest that photobiomodulation exhibits an effect on glycemic and lipid profiles in vitro. Hence, the use of low-level laser therapy could have therapeutic potential. However, the differences between individual responses appear to indicate that the impact of PBMT may not always be beneficial.

Keyword

Cholesterol; Glucose; Laser therapy; Photo-biomodulation; Triglycerides