Korean J Intern Med.  2022 Sep;37(5):895-905. 10.3904/kjim.2022.132.

Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α

• Park J
• Cheon JH

• KMID: 2533132
• DOI: http://doi.org/10.3904/kjim.2022.132

Abstract

The incidence and prevalence of inflammatory bowel diseases (IBDs) are rapidly increasing worldwide. IBDs are considered an emerging problem not only in Western countries but also in developing counties. The relapses and complications of active IBD mandate various medications. Nevertheless, hospitalization, emergency room visits, or surgery may be required, resulting in a socioeconomic burden. Great advances have been made in the development of new therapeutic options for IBD to achieve induction and maintenance remission. Nevertheless, conventional therapy is still the mainstay in the treatment of IBD. This review article provides an update on recent advances in conventional therapies, including 5-aminosalicylates, corticosteroids, immunomodulators, and anti-tumor necrosis factor-α agents to treat IBD.

Keyword

Inflammatory bowel diseases; Mesalamine; Adrenal cortex hormones; Immunologic factors; Anti-TNF agents