Korean J Physiol Pharmacol.  2022 Sep;26(5):297-305. 10.4196/kjpp.2022.26.5.297.

Effects of sleep deprivation on coronary heart disease

• Wei R
• Duan X
• Guo L

• KMID: 2532759
• DOI: http://doi.org/10.4196/kjpp.2022.26.5.297

Abstract

The presence of artificial light enables humans to be active 24 h a day. Many people across the globe live in a social culture that encourages staying up late to meet the demands of various activities, such as work and school. Sleep deprivation (SD) is a severe health problem in modern society. Meanwhile, as with cardiometabolic disease, there was an obvious tendency that coronary heart disease (CHD) to become a global epidemic chronic disease. Specifically, SD can significantly increase the morbidity and mortality of CHD. However, the underlying mechanisms responsible for the effects of SD on CHD are multilayered and complex. Inflammatory response, lipid metabolism, oxidative stress, and endothelial function all contribute to cardiovascular lesions. In this review, the effects of SD on CHD development are summarized, and SD-related pathogenesis of coronary artery lesions is discussed. In general, early assessment of SD played a vital role in preventing the harmful consequences of CHD.

Keyword

Coronary heart disease; Inflammatory response; Lipid metabolism; Oxidative stress; Sleep deprivation

Figure

• 

  Fig. 1 Sleep deprivation and the pathogenesis of coronary heart disease. NR1D1, nuclear receptor subfamily 1 group D member 1; CYP7A1, cholesterol 7α-hydroxylase; IRE1α ,Inositol-requiring enzyme-1α; CCL2, chemokine C-C motif ligand 2; CCR2, chemokine C-C-motif receptor 2; CCGs, CLOCK control genes; BMAL2, brain-muscle-ARNT-like protein-2; PAI-1, plasminogen activator inhibitor-1; TM, thrombomodulin; PI3K, phosphatidyl inositol-3 kinase; Akt, protein kinase B; eNOS, endothelial nitric oxide synthase; NO, nitric oxide; cGMP, cyclic guanosine monophosphate; cAMP, cyclic adenosine monophosphate; PKA, protein kinase A; TLR, toll-like receptor; NF-κB, nuclear factor kappa B.

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