Sleep Med Psychophysiol.  2003 Dec;10(2):108-112.

Effects of Total Sleep Deprivation on Auditory Event-Related Potentials

Affiliations
  • 1Department of Neuropsychiatry, Korea University College of Medicine, Seoul, Korea.

Abstract


OBJECTIVE
The purpose of this study is to investigate the psychophysiological effects of total sleep deprivation by using auditory event-related potentials.
METHODS
Twenty four healthy college students (18 men, 6 women) participated in this study. The subjects remained awake for 37 hours under continuous surveillance. In the morning and the evening of two consecutive study days, auditory event-related potentials were checked.
RESULTS
The latencies of P300 and N200 were significantly prolonged (p<0.001) and their amplitudes decreased (p<0.05) as a consequence of sleep deprivation. The amplitude of P200 was significantly increased during sleep deprivation (p<0.05). However, there was no significant change in the latency and amplitude of N100.
CONCLUSIONS
Among the components of auditory event-related potentials, P300 and N200 are good indicators of sleep-deprived status. Further investigation is necessary to elucidate the neurophysiological mechanisms of these findings.

Keyword

Sleep deprivation; Auditory event-rated potential

MeSH Terms

Event-Related Potentials, P300
Evoked Potentials*
Humans
Male
Sleep Deprivation*
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