Allergy Asthma Respir Dis.
2022 Jul;10(3):139-144. 10.4168/aard.2022.10.3.139.
Effects of outdoor air pollution on children with allergic rhinitis
- Sung M1
- Kim M2
- Kim HH3
- Rha YH4
- Park Y5
- Park YM6
- Sheen YH7
- Yum HY8
- Lee KS9
- Lee YJ10
- Chun YH3
- Jee HM11
- Choi BS12
- Choi SH4
- Kim HB
13 - for the Rhinitis Study Group in the Korean Academy of Pediatric Allergy and Respiratory Diseases
- Affiliations
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- 1Department of Pediatrics, Soonchunhyang University Gumi Hospital, Gumi, Korea
- 2Department of Pediatrics, Chungnam National University Sejong Hospital, Sejong, Korea
- 3Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
- 4Department of Pediatrics, School of Medicine, Kyung Hee University, Seoul, Korea
- 5Department of Pediatrics, Wonkwang University Sanbon Hospital, Gunpo, Korea
- 6Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
- 7Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea
- 8Department of Pediatrics, Seoul Medical Center, Seoul, Korea
- 9Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea
- 10Department of Pediatrics, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea
- 11Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
- 12Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea
- 13Department of Pediatrics, Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
- KMID: 2532267
- DOI: http://doi.org/10.4168/aard.2022.10.3.139
Abstract
- The global worsening of air pollution has decreased the quality of life. Air pollutants can induce oxidative stress, epigenetic changes, and alterations to microRNA expression in the airway and skin, leading to immune dysregulation. Previous epidemiological studies suggest a strong association between outdoor environmental pollution and childhood allergic disease, especially allergic rhinitis (AR). Moreover, traffic-related air pollution has increased the severity and incidence of AR, and heavy traffic has been associated with an increased prevalence of AR. Thus, this review aimed to define outdoor environmental pollution and clarify the mechanisms by which air pollutants aggravate AR. In addition, we performed a systematic review and meta-analysis to summarize the findings of several domestic and international epidemiological and clinical studies about the effects of air pollution on AR in children.
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