J Korean Med Assoc.  2022 Jun;65(6):353-360. 10.5124/jkma.2022.65.6.353.

Planned oocyte cryopreservation for fertility preservation

• Lee D
• Kim YJ

• KMID: 2531605
• DOI: http://doi.org/10.5124/jkma.2022.65.6.353

Abstract

Background
Oocyte cryopreservation opens up opportunities for women to preserve fertility when it is necessary to postpone pregnancy. After the advent of vitrification, the results of oocyte cryopreservation were significantly improved compared to conventional slow-freezing. Through these improvements, oocyte cryopreservation was introduced to overcome a decline in fecundity due to an increase in age, and this modality is defined as planned oocyte cryopreservation.
Current Concepts
Oocytes cryopreserved through vitrification appear to result in similar clinical pregnancy rates and live birth rates compared to fresh oocytes, though the evidence is still limited. It has been reported that the live birth rate increases when the planned oocyte cryopreservation is performed at a younger age. Obstetrical and neonatal outcomes appear similar between vitrified and fresh oocytes.
Discussion and Conclusion
Preliminary data supports planned oocyte cryopreservation as a feasible modality resulting in fertility preservation and subsequent live births. The fact that performing the procedure at a younger age can increase the oocyte yield, oocyte efficacy, and live birth rate can be discussed along with patient consultation. However, as there is still a lack of data on the standardized live birth rate, the number of oocytes to be collected, and the long-term effect on the children; more well-designed studies are needed to improve counseling and decision-making in patients seeking this treatment.

Keyword

Cryopreservation; Oocytes; Vitrification; Fertility preservation; 동결 보존; 난자; 유리화; 가임력 보존