J Korean Med Assoc.  2022 Jun;65(6):329-337. 10.5124/jkma.2022.65.6.329.

Fertility preservation for patients with cancer

• Lee S
• Kim T

• KMID: 2531602
• DOI: http://doi.org/10.5124/jkma.2022.65.6.329

Abstract

Background
The survival rate of cancer patients is increasing owing to the early diagnosis and treatment methods. Radiotherapy and chemotherapy may cause serious complications, such as ovarian failure and infertility. In particular, preservation of fertility in women of reproductive age with cancer could improve their quality of life as well as reduce social and psychological pain.
Current Concepts
Embryo or oocyte cryopreservation is a method of fertility preservation; however, it cannot be utilized by all women with cancer because of the complications of the condition and treatment method. Ovarian tissue cryopreservation and transplantation enables fertility preservation in those needing immediate cancer treatment, such as chemotherapy or radiotherapy, or those unqualified for ovarian stimulation. A recent review reported that frozen-thawed ovarian transplantation led to approximately 130 live births with a conception rate of approximately 30%. Endocrine function recovery occurred in 92.9% of the patients between 3.5 and 6.5 months after transplantation.
Discussion and Conclusion
In this study, we introduced various methods and strategies for improving the outcomes of ovarian tissue cryopreservation and transplantation. These results could serve as a reference for patients and clinicians to choose the best options for fertility preservation based on the patient’s current situation and condition.

Keyword

Fertility preservation; Ovary; Cryopreservation; Tissue transplantation; 가임력 보존; 난소종양; 냉동 보존; 조직 이식