Tissue Eng Regen Med.  2022 Jun;19(3):451-461. 10.1007/s13770-022-00432-w.

The Progress of Decellularized Scaffold in Stomatology

• Zeng A
• Li H
• Liu J
• Wu M

• KMID: 2530140
• DOI: http://doi.org/10.1007/s13770-022-00432-w

Abstract

The oral and maxillofacial region contains oral organs and facial soft tissues. Due to the complexity of the structures and functions of this region, the repair of related defects is complicated. Different degrees of defects require different repair methods, which involve a great combination of medicine and art, and the material requirements are extremely high. Hence, clinicians are plagued by contemporary oral repair materials due to the limitations of bone harvesting, immune rejection, low osteogenic activity and other problems. Decellularized extracellular matrix has attracted much attention as a bioactive scaffold material because of its nonimmunogenic properties, good osteogenic properties, slow release of growth factors, promotion of seed cell adhesion and maintenance of stem cell characteristics. This article reviews the sources, preparation methods, application and research progress of extracellular matrix materials in the repair of oral and maxillofacial defects to provide an overview for fundamental research and clinical development.

Keyword

Extracellular matrix; Decellularization; Stomatology; Scaffold