J Korean Soc Radiol.  2022 May;83(3):508-526. 10.3348/jksr.2022.0044.

MRI Findings in Parkinson’s Disease: Radiologic Assessment of Nigrostriatal Degeneration

Affiliations
  • 1Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
  • 2Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • 3Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • 4Division of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea.

Abstract

Parkinson’s disease (PD) is a movement disorder that develops due to degenerative loss of dopaminergic cells in the substantia nigra of the midbrain. Recent advances in MRI techniques have demonstrated various imaging findings that can reflect the underlying pathophysiological processes occurring in Parkinson’s disease. Many imaging studies have shown that such findings can assist in the diagnosis of Parkinson’s disease and its differentiation from atypical parkinsonism. In this review, we present MRI techniques that can be used in clinical assessment, such as nigrosome imaging and neuromelanin imaging, and we provide the detailed imaging features of Parkinson’s disease reflecting nigrostriatal degeneration.

Keyword

Parkinson Disease; Magnetic Resonance Imaging; Substantia Nigra
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