J Korean Soc Radiol.
2022 May;83(3):486-507. 10.3348/jksr.2022.0041.
Association between Cerebral Small Vessel and Alzheimer’s Disease
- Affiliations
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- 1Department of Radiology, Seoul National University Hospital, Seoul, Korea.
- 2Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 2530069
- DOI: http://doi.org/10.3348/jksr.2022.0041
Abstract
- Cerebral small vessel disease (CSVD) includes vascular lesions detected on brain MRI, such as white matter hyperintensities, lacunar infarctions, microbleeds, or enlarged perivascular spaces. There is accumulating evidence that vascular changes may play an important role in development of Alzheimer’s disease (AD), and CSVD lesions detected on brain MRI were reported to be associated with β-amyloid and tau proteins accumulation. As the vascular contribution has therapeutic potential, it is important to understand the association of CSVD with AD and AD biomarkers. This review begins with a brief introduction of AD and AD biomarkers, explains the association between AD and vascular changes, and then details the pathogenesis and MR imaging findings of CSVD. Afterwards, we discuss the association of CSVD with AD and AD biomarkers.
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