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Melatonin and Alzheimer’s Disease: A Mini-Review

Um YH, Lim HK

Melatonin is a hormone with neuroregulatory, antioxidant and anti-inflammatory properties. Its benevolent effects on Alzheimer’s disease (AD) has been replicated in both animal models and clinical studies. Melatonin was effective...
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Clinical Application of Plasma Neurofilament Light Chain in a Memory Clinic: A Pilot Study

Shim Y

Background and Purpose: Neurofilament light chain (NfL) has been considered as a biomarker for neurodegenerative diseases including Alzheimer’s disease (AD). We measured plasma NfL levels in older adults with cognitive...
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Executive Summary of the 2021 International Conference of Korean Dementia Association: A Report From the Academic Committee of the Korean Dementia Association

Park KH, Jang JW, Suh J, Yi S, Bae JS, Lim JS, Lee H, Chin J, Park YH, Hong YJ, Kim GH, oboACotKDA

Recently, aducanumab, a beta amyloid targeted immunotherapy, has been approved by the US Food and Drug Administration for the treatment of Alzheimer’s dementia (AD). Although many questions need to be...
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Impact of Testosterone on Alzheimer’s Disease

Bianchi VE

Alzheimer’s disease (AD) is a neurodegenerative disease responsible for almost half of all dementia cases in the world and progressively increasing. The etiopathology includes heritability, genetic factors, aging, nutrition, but...
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Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta

Lee S, Choi WS

Alzheimer’s disease (AD) is the most common cause of neurodegeneration. It is characterized by deposits of amyloid beta (Aβ) plaques and impaired memory. Microglia are associated with AD. They are...
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Exploring Factors Associated With Successful Nonpharmacological Interventions for People With Dementia

Park HG, Perumean-Chaney SE, Bartolucci AA

Background and purpose: We investigated existing nonpharmacological programs for people with dementia (PWD) to explore critical factors related to the effectiveness of these types of programs. Methods: We conducted a qualitative...
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Correlation between Alteration of Sharp-wave Ripple Coupled Cortical Oscillation and Long-term Memory Deficit in Alzheimer Disease Model Mice

Yang H, Jeong Y

  • KMID: 2524039
  • Exp Neurobiol.
  • 2021 Dec;30(6):430-440.
  • doi: 10.5607/en21046
Alzheimer’s disease (AD) is the most common cause of dementia, characterized by prominent episodic memory dysfunction. Recent studies have suggested that there is a sequential mechanism in the memory deficit,...
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Decreased Cortical Thickness and Local Gyrification in Individuals with Subjective Cognitive Impairment

Youn H, Choi M, Lee S, Kim D, Suh S, Han CE, Jeong HG

Objective: Subjective cognitive impairment (SCI) is associated with future cognitive decline. This study aimed to compare cortical thickness and local gyrification index (LGI) between individuals with SCI and normal control...
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Association of Antipsychotics and Behavioral and Psychological Symptoms of Dementia With Cognitive Decline in Subjects With Alzheimer’s Disease

Chang JH, Jon D, Hong HJ, Jung MH, Hong N

Objective: Neuropsychiatric symptoms are common among patients with major neurocognitive disorder. Antipsychotic medica-tions have been widely used to manage behavioral and psychological symptoms of dementia (BPSD), however efficacy and safety...
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Analysis of behavioral management for dental treatment in patients with dementia using the Korean National Health Insurance data

Kim T, Chi SI, Kim H, Seo KS

Background: The global population is aging rapidly, and accordingly, the number of patients with dementia is increasing every year. Although the need for dental treatment increases for various reasons in...
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A Comparison of Speech Features between Mild Cognitive Impairment and Healthy Aging Groups

Kim KW, Na SH, Chung YC, Shin BS

Background and Purpose: Language dysfunction is a symptom common to patients with Alzheimer's disease (AD). Speech feature analysis may be a patient-friendly screening test for early-stage AD. We aimed to...
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Electroacupuncture ameliorates blood-brain barrier dysfunction in 5XFAD Alzheimer’s animal model

Cai M, Lee JH, Yang EJ

Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disease accompanied by aging, followed by memory impairment and cognitive decline. Although numerous attempts have been made to develop treatments for...
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Cardiovascular Complications of Acetylcholinesterase Inhibitors in Patients with Alzheimer’s Disease: A Narrative Review

Young S, Chung E, Chen MA

While acetylcholinesterase inhibitors are used to treat a wide range of patients with Alzheimer’s disease, acetylcholinesterase inhibitor use has also been associated with a variety of cardiovascular complications, including bradycardia...
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Novel Biomarkers of Alzheimer’s Disease: Based Upon N-methylD-aspartate Receptor Hypoactivation and Oxidative Stress

Chiang TI, Yu YH, Lin CH, Lane HY

Early detection and prevention of Alzheimer's disease (AD) is important. The current treatment for early AD is acetylcholine esterase inhibitors (AChEIs); however, the efficacy is poor. Besides, AChEI did not...
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Effects of Electrical Automatic Massage on Cognition and Sleep Quality in Alzheimer’s Disease Spectrum Patients: A Randomized Controlled Trial

Kim YJ, Kim HR, Jung YH, Park YH, Seo SW

Purpose: Muscle relaxation following electrical automatic massage (EAM) has been found to reduce fatigue, depression, stress, anxiety, and pain in individuals with various conditions. However, the effects of EAM have...
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Finding the optimal cutoff value for amyloid β positivity using the iterative outlier method and concordance rate

Kim HR, Choe YS, Moon SH, Kim HJ, Jang H, L.Na D, Park S, Seo SW

Purpose: The purpose of this study was to calculate the cutoff value for amyloid β (Aβ) positron emission tomography (PET) positivity using the iterative outlier method and to evaluate its...
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Proton-pump Inhibitors and the Risk of Dementia: A Systematic Review and Meta-analysis

Yoon KT, Bang CS, Kim JS

Background/Aims: Proton pump inhibitors (PPIs) are widely used to treat several acid-related gastrointestinal disorders. This study aimed to investigate the risk of dementia in patients taking PPIs. Materials and Methods: A...
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Treadmill Running Improves Spatial Learning Memory Through Inactivation of Nuclear Factor Kappa B/Mitogen-Activated Protein Kinase Signaling Pathway in Amyloid-β-Induced Alzheimer Disease Rats

Kim SH, Ko YJ, Kim JY, Sim YJ

Purpose: Exercise is known to reduce proinflammatory cytokines production and apoptosis. We investigated the effect of treadmill running on spatial learning memory in terms of activation of nuclear factor kappa...
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Pathobiolgy and Management of Alzheimer’s Disease

Kim H, Chung JY

Amyloid and tau protein abnormalities have been identified as the main causes of Alzheimer’s disease but exact mechanisms remain to be revealed. Especially, amyloid beta and tau protein coupling and...
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Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study

Cho Y, Han K, Kim DH, Park YM, Yoon KH, Kim MK, Lee SH

Background: Metabolic disturbances are modifiable risk factors for dementia. Because the status of metabolic syndrome (MetS) and its components changes over time, we aimed to investigate the association of the...
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