Int J Stem Cells.  2022 May;15(2):113-121. 10.15283/ijsc21122.

In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges

• Founta KM
• Papanayotou C

• KMID: 2529783
• DOI: http://doi.org/10.15283/ijsc21122

Abstract

The ultimate goal of regenerative medicine is to replace damaged cells, tissues or whole organs, in order to restore their proper function. Stem cell related technologies promise to generate transplants from the patients’ own cells. Novel approaches such as blastocyst complementation combined with genome editing techniques open up new perspectives for organ replacement therapies. This review summarizes recent advances in the field and highlights the challenges that still remain to be addressed.

Keyword

Blastocyst complementation; Chimeras; Organ generation; Transplantation

Reference

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