J Korean Neurol Assoc.
2022 May;40(2):172-175. 10.17340/jkna.2022.2.13.
Transient Mutism Related to Capecitabine-Induced Acute Toxic Leukoencephalopathy
- Affiliations
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- 1Department of Neurology, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, Korea
- KMID: 2529612
- DOI: http://doi.org/10.17340/jkna.2022.2.13
Abstract
- Capecitabine, a precursor of 5-fluorouracil (5-FU), is a well-tolerated and safe chemotherapy that has been used to treat breast, pancreatic, and colorectal cancers. Albeit rare, both 5-FU and capecitbine have been reported to be associated with acute central nervous system toxicity, including cerebellar dysfunction, posterior reversible encephalopathy syndrome, and transient leukoencephalopathies. Here we present a case of 32-year-old female, demonstrating transient mutism related to capecitabine induced acute toxic leukoencephalopathy.
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