J Korean Neurol Assoc.
2022 May;40(2):156-159. 10.17340/jkna.2022.2.9.
Neuronal Intranuclear Inclusion Disease with Abnormal Peripheral Nerve Conduction
- Affiliations
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- 1Department of Neurology, Kyungpook National University Hospital, Daegu, Korea
- 2Department of Pathology, Kyungpook National University Hospital, Daegu, Korea
- 3Department of Pathology, School of Medicine, Kyungpook National University, Daegu, Korea
- 4Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea
- KMID: 2529608
- DOI: http://doi.org/10.17340/jkna.2022.2.9
Abstract
- A 70-year-old female presented with progressive gait disturbance. Neurologic examination revealed sensory impairment, hyporeflexia, and sensory ataxia. Nerve conduction study demonstrated mildly decreased velocity in motor nerves. Brain magnetic resonance imaging showed high signal intensities in the corticomedullary junction on diffusion weighted imaging. Neurocognitive function test implied mild cognitive impairment. Based on eosinophilic intranuclear inclusions in pathology, neuronal intranuclear inclusion disease was confirmed. Neuronal intranuclear inclusion needs to be considered when abnormal nerve conduction studies are consistent with abnormal brain imaging findings.
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