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Regional Metabolic Changes Influencing Three-Dimensional Perception in Parkinson’s Disease

Park Y, Park KW, Lee CN

Background and Purpose Stereopsis refers to the perception of depth and awareness of the distance of an object from the observer that results from the brain receiving visual stimuli from...
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An Enlarged Perivascular Space: Clinical Relevance and the Role of Imaging in Aging and Neurologic Disorders

Yim Y, Moon WJ

The perivascular space (PVS) of the brain, also known as Virchow-Robin space, consists of cerebrospinal fluid and connective tissues bordered by astrocyte endfeet. The PVS, in a word, is the...
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Neuronal Intranuclear Inclusion Disease with Abnormal Peripheral Nerve Conduction

Jeong A, Kim Y, Ryu HS, Han MH, Lee JM

A 70-year-old female presented with progressive gait disturbance. Neurologic examination revealed sensory impairment, hyporeflexia, and sensory ataxia. Nerve conduction study demonstrated mildly decreased velocity in motor nerves. Brain magnetic resonance...
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Physiological Roles of Monomeric Amyloid-β and Implications for Alzheimer’s Disease Therapeutics

Jeong H, Shin H, Hong S, Kim Y

Alzheimer’s disease (AD) progressively inflicts impairment of synaptic functions with notable deposition of amyloid-β (Aβ) as senile plaques within the extracellular space of the brain. Accordingly, therapeutic directions for AD...
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Translocator Protein (18 kDa) Polymorphism (rs6971) in the Korean Population

Lee H, Noh Y, Kim WR, Seo HE, Park HM

Background and Purpose: The expression of the 18-kDA mitochondrial translocator protein (TSPO) in the brain is an attractive target to study neuroinflammation. However, the binding properties of TSPO ligands are...
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Protective effects of Populus tomentiglandulosa against cognitive impairment by regulating oxidative stress in an amyloid beta25–35 -induced Alzheimer's disease mouse model

Kwon YR, Kim JH, Lee S, Kim HY, Cho EJ

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is one of the most representative neurodegenerative disease mainly caused by the excessive production of amyloid beta (Aβ). Several studies on the antioxidant activity and protective effects...
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The Association Between Cancer and Neurodegenerative Diseases: A Retrospective Cohort Study Using the National Health Insurance Service-National Health Information Database

Kim JH, Kim YT, Lee HJ, Kim HC

Objectives According to previous studies, cancer risk has decreased among patients with neurodegenerative disease (ND). However, some types of cancer are positively associated with ND. ND and cancer share common mechanisms...
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Methyl Jasmonate: Behavioral and Molecular Implications in Neurological Disorders

Aluko OM, Iroegbu JD, Ijomone OM, Umukoro S

Methyl jasmonate (MJ) is a derivative of the jasmonate family which is found in most tropical regions of the world and present in many fruits and vegetables such as grapevines,...
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Impact of Neurodegenerative Disease on the Development of Cancer in Elderly Koreans: A 10-Year Cohort Study Using National Health Insurance Database

Lee SY, Kim JH, Kim JB, Kim YT, Lee HJ, Kim HC

Objective: We evaluated the association between cancer and various neurodegenerative diseases (NDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), and circumscribed brain atrophy (CBA) and to evaluate the impact of...
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Induced neural stem cells from human patient-derived fibroblasts attenuate neurodegeneration in Niemann-Pick type C mice

Hong S, Lee SE, Kang I, Yang J, Kim H, Kim J, Kang KS

Background: Niemann-Pick disease type C (NPC) is caused by the mutation of NPC genes, which leads to the abnormal accumulation of unesterified cholesterol and glycolipids in lysosomes. This autosomal recessive...
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Cohort profile: the Environmental-Pollution-Induced Neurological EFfects (EPINEF) study: a multicenter cohort study of Korean adults

Jang H, Kim W, Cho J, Sohn J, Noh J, Seo G, Lee SK, Noh Y, Oh SS, Koh SB, Kim HJ, Seo SW, Kim HH, Lee JI, Kim SY, Kim C

The general population is exposed to numerous environmental pollutants, and it remains unclear which pollutants affect the brain, accelerating brain aging and increasing the risk of dementia. The Environmental-Pollution-Induced Neurological...
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Paeoniflorin ameliorates Aβ-stimulated neuroinflammation via regulation of NF-κB signaling pathway and Aβ degradation in C6 glial cells

Cho EJ, Kim HY, Lee AY

BACKGROUND/OBJECTIVES: Alzheimer's disease is common age-related neurodegenerative condition characterized by amyloid beta (Aβ) accumulation that leads cognitive impairment. In the present study, we investigated the protective effect of paeoniflorin (PF) against...
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An Optimization of AAV-82Q-Delivered Rat Model of Huntington’s Disease

So KH, Choi JH, Islam J, KC E, Moon HC, Won SY, Kim HK, Kim S, Hyun SH, Park YS

Objective : No optimum genetic rat Huntington model both neuropathological using an adeno-associated virus (AAV-2) vector vector has been reported to date. We investigated whether direct infection of an AAV2...
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Manipulated Mesenchymal Stem Cells Applications in Neurodegenerative Diseases

Sadatpoor , Salehi Z, Rahban D, Salimi A

Mesenchymal stem cells (MSCs) are multipotent stem cells that have multilinear differentiation and self-renewal abilities. These cells are immune-privileged as they express no or low level of class-II major histocompatibility...
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Neuroprotective effects of urolithin A on Hâ‚‚Oâ‚‚-induced oxidative stress-mediated apoptosis in SK-N-MC cells

Kim KB, Lee S, Kim JH

BACKGROUND/OBJECTIVES: Oxidative stress causes cell damage and death, which contribute to the pathogenesis of neurodegenerative diseases. Urolithin A (UA), a gut microbial-derived metabolite of ellagitannins and ellagic acid, has high...
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The phenomenology of pain in Parkinson’s disease

Camacho-Conde JA, Campos-Arillo VM

Background: Parkinson’s disease (PD) is a neurodegenerative disorder that is the second most common disorder after Alzheimer’s disease. PD includes both “motor” and “non-motor” symptoms, one of which is pain....
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Big data differential analysis of microglial cell responses in neurodegenerative diseases

Tabassum R, Jeong NY, Chung HJ

Microarray technology has become an indispensable tool for monitoring the levels of gene expression in a given organism through organization, analysis, interpretation, and utilization of biological sequences. Importantly, preliminary microarray...
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Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends

Hong N

Photobiomodulation (PBM) is a rapidly growing as an innovative therapeutic modality for various types of diseases in recent years. Neuronal degeneration is irreversible process and it is proven to be...
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Effects and Mechanisms of Taurine as a Therapeutic Agent

Schaffer S, Kim HW

Taurine is an abundant, β-amino acid with diverse cytoprotective activity. In some species, taurine is an essential nutrient but in man it is considered a semi-essential nutrient, although cells lacking...
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Microglial involvement in the development of olfactory dysfunction

Seo Y, Kim HS, Kang KS

Olfactory impairment is the most common clinical manifestation among the elderly, and its prevalence increases sharply with age. Notably, growing evidence has shown that olfactory dysfunction is the first sign...
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