Tuberc Respir Dis.  1988 Mar;35(1):38-43. 10.4046/trd.1988.35.1.38.

T-Cell Subset in Patients with Lung Cancer(1)

• KMID: 2528624
• DOI: http://doi.org/10.4046/trd.1988.35.1.38

Abstract

The authors studied T.lymphocyte subset and delayed skin hypersensitivity in 48 patients with bronchogenic carcinoma. 1) The percentage of Iymphocyte and total Iymphocyte counts significantly decreased in patient group (P < 0.002). 2) Percent of OKT8⁺ T-lymphocyte decreased and OKT4⁺ / OKT8⁺ ratio increased in patient group (especialJ y squamous cell lung cancer and adenocarcinoma) (P<0.05). 3) Percent of OKT8⁺ cells significantly decreased in stage III but not in stage I & II of nonsmall cell lung cancer (P < 0.05). 4) Numbers and total scores of positive reactions in CMI multitest significantly decreased inpatient group (P < 0.005) Decreased cellular immune function in patients with lung cancer may be associated with progression of disease and risk of opportunistic infection. Although it is not clear whether altered immune function occurs only as a results of advanced disease or develops in certain patients predisposing them to further spread of tumor, it is important to assess cellular immune function in lung cancer patients.