Tuberc Respir Dis.  1988 Jun;35(2):110-119. 10.4046/trd.1988.35.2.110.

Study of Serum Alpha1 Antitrypsin Levels and Protease Inhibitor System in Korean Patients with Chronic Obstructive Pulmonary diseases

• KMID: 2528612
• DOI: http://doi.org/10.4046/trd.1988.35.2.110

Abstract

In Korea, Pi phenotype of severe α₁-antitrypsin deficiency has been to be rare, but it has not been perforrned the study on Pi phenotype in patients with chronic obstructive pulmonary disease. The serum α₁-antitrypsin levels, the Pi phenotype, and subtype of PiM have studied in 45 patients with chronic obstructive pulmonary disease, 57 patients with other lung diseases, and 364 normal persons. The results were as follows: 1) The mean values of α₁-antitrypsin level was 262 ± 97 mg/ dL in chronic obstructive pulmonary disease, 263 ± 97 mg/ dL in other lung diseases, and 198 ± 30 mg/ dL in healthy control. There are statistical differences of α₁-antitrypsin level between chronic obstructive pulmonary disease and healthy control with significance (P < 0.05). 2) Forty four cases were subtype of PiM among 45 patients with chronic obstructive pulmonary disease patients and another 1 cases was PiM₁ Z. All patients with other lung disease were PiM subtype. 3) The prevalence of PiM subtype were M₁M₁ 59.1%, M₂M₂ 2.3%, M₃M₃ 0%, M₁M₂ 15.9%, M₂M₃ 9.1 %, and M₁M₃ 13.6% in patients with chronic obstructive pulmonary disease. There was no significant statistical difference in the prevalence of PiM subtype, comparing to PiM subtypes of other lung disease and healthy control (p> 0.05). 4) Allele frequencies of Pi system were estimated to be M₁ 0.7333, M₂ 0.1444, M₃ 0.1111, and Z 0.0111 in patients with chronic pulmonary disease. The results of X²-test for deviation from Hardy-Weinberg equilibrium was no statistical difference with significance (p>0.05).