J Korean Surg Soc.  1997 Jun;52(6):846-851.

Changing patterns of Pancreatic enzyme after Distal Gastrectomy and the Effect of Protease Inhibitor Treatment

• Oh ST
• Kim WS
• Kim BS

Abstract

We have reported that serum amylase and lipase level elevate immediately after total gastrectomy independent to whether the pancreas is manipulated or not. Although we found high levels of amylase and lipase from the draining fluid via intraabdominal drain, none of them became pancreatic fistula. To check the amylase and lipase level after distal gastrectomy and to check whether the protease inhibitor (gabexate mesilate) reduce the elevated amylase and lipase, we made a prospective study. A Jackson-Pratt drain was inserted intraperitoneally during the operation to check amylase and lipase levels postoperatively. We present the postoperative changing patterns of amylase and lipase levels in the draining fluid. Serum amylase and lipase levels were also monitored. We found elevation of amylase and lipase concentrations in the draining fluid for a few days after distal gastrectomy. However, none of the patients developed pancreatic fistula, although all of the surgical methods showed hyperamylasemia and hyperlipasemia. Postoperative treatment with protease inhibitor was not effective against the elevated amylase and lipase levels in serum or draining fluid.

Keyword

Gastrectomy; Protease inhibitor; Amylase; Lipase; FOY

MeSH Terms

Amylases
Gabexate
Gastrectomy*
Humans
Hyperamylasemia
Lipase
Pancreas
Pancreatic Fistula
Prospective Studies
Protease Inhibitors*
Amylases
Gabexate
Lipase
Protease Inhibitors