Korean J Intern Med.  2022 Mar;37(2):387-397. 10.3904/kjim.2021.025.

Prevalence and impact of airway diseases on clinical outcomes in idiopathic pulmonary fibrosis

• Park H
• Cho J
• Lee J
• Park YS
• Lee CH
• Lee SM
• Yoo CG
• Kim YW
• Han SK
• Choi SM

• KMID: 2527302
• DOI: http://doi.org/10.3904/kjim.2021.025

Abstract

Background/Aims
The prevalence and effects of airway diseases, including asthma, eosinophilic bronchitis (EB), chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO) have not been thoroughly studied in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to evaluate the prevalence of airway diseases in patients with IPF and to identify the differences in symptoms based on the presence of airway diseases.
Methods
This single-institution prospective cohort study was conducted from June 2017 to September 2018, at the Seoul National University Hospital. Spirometry with bronchodilator, methacholine bronchial provocation test, induced sputum with eosinophil stain, and exhaled nitric oxide were performed to confirm the presence of airway disease. The modified Medical Research Council (mMRC) dyspnea scale, COPD assessment test (CAT), St. George’s Respiratory Questionnaire (SGRQ), EuroQol-5 dimension (EQ-5D) index, and cough-specific quality of life questionnaire (CQLQ) data were collected to assess symptom severity.
Results
Total 147 patients with IPF were screened, and 70 patients were analyzed. The prevalence of airway diseases in the participants was as follows: 5.0% had COPD, 1.7% had asthma, 3.3% had ACO, and 1.7% had EB. The mMRC, CAT, SGRQ, EQ-5D, and CQLQ scores did not differ regardless of combined airway disease. After 3 months, the SGRQ (p = 0.028) and CQLQ (p = 0.030) scores were significantly higher in patients with airway disease than in those without.
Conclusions
The prevalence of airway diseases in patients with IPF is low, but when airway diseases are accompanied by IPF, symptom severity and quality of life may worsen rapidly.

Keyword

Idiopathic pulmonary fibrosis; Asthma; Pulmonary disease, chronic obstructive; Asthma-chronic obstructive pulmonary disease overlap syndrome; Respiratory therapy