Transl Clin Pharmacol.  2021 Jun;29(2):88-91. 10.12793/tcp.2021.29.e8.

Acetaminophen-induced anaphylaxis: a case report

  • 1Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
  • 2Department of Emergency Medical Services, College of Health Sciences, Eulji University, Seongnam 13135, Korea


Acetaminophen is known to be generally safe, and the occurrence of anaphylaxis due to acetaminophen has been rarely reported. We report a case of acetaminopheninduced anaphylaxis in a healthy male subject who participated in a clinical trial on the pharmacokinetics of ibandronate. The subject had not experienced an allergic reaction to acetaminophen prior to this incident. The patient received 1300 mg oral acetaminophen at about 12 hours after receiving 150 mg ibandronate. After about 10 minutes, the subject developed whole-body urticaria and hypotension. The temporal association suggested that the anaphylaxis was due to acetaminophen and not ibandronate. Anaphylaxis could occur due to acetaminophen even in the absence of allergic reactions in the first dosing.


Acetaminophen; Anaphylaxis; Drug Hypersensitivity
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