Tissue Eng Regen Med.
2022 Feb;19(1):83-92. 10.1007/s13770-021-00416-2.
Synergistic Effect of Whitlockite Scaffolds Combined with Alendronate to Promote Bone Regeneration
- Affiliations
-
- 1Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea
- 2R&D Center, OSFIRM Co., Ltd., Seongnam-si, Gyeonggi-do, Republic of Korea
- 3Department of Research Administration Team, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea
- 4Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea
- 5Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, Republic of Korea
- 6Medical Research Center, Institution of Medical & Biological Engineering, Seoul National University, Seoul, Republic of Korea
- 7Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea
- KMID: 2525408
- DOI: http://doi.org/10.1007/s13770-021-00416-2
Abstract
- BACKGROUND
Due to the increasing aging of society, the number of patients suffering from senile diseases is increasing. Patients suffering from osteoporosis, which is a representative senile disease, take a long time to recover from fractures, and the resulting mortality rate is very high. Alendronate (Ald), which is widely used as a treatment for osteoporosis, alleviates osteoporosis by inhibiting osteoclasts. In addition, whitlockite (WH) promotes the osteogenic differentiation of bone cells and improves bone regeneration. Therefore, we intended to bring about a synergistic effect by using these substances together.
METHODS
In this study, a scaffold composed of gelatin/heparin was fabricated and applied to effectively use WH and Ald together. A scaffold was constructed using gelatin and heparin was used to effectively utilize the cations released from WH. In addition, it formed a porous structure for effective bone regeneration. In vitro and in vivo osteoclast inhibition, osteogenic differentiation, and bone regeneration were studied using the prepared scaffolds.
RESULTS
The inhibition of osteoclast was much higher when WH and Ald were applied in combination rather than individually. The highest level of osteogenic differentiation was observed when both substances were applied simultaneously. In addition, when applied to bone regeneration through the mouse calvarial defect model, combined treatment showed excellent bone regeneration.
CONCLUSION
Therefore, this study showed the synergistic effect of WH and Ald, and it is suggested that better bone regeneration is possible by applying this treatment to bones with fractures that are difficult to regenerate.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Effect of Alendronate on Bone Regeneration in Defect of Rat Calvaria
- Biomimetic Polymer Scaffolds to Promote Stem Cell-Mediated Osteogenesis
- Comparative Study of BMP-2 Alone and Combined with VEGF Carried by Hydrogel for Maxillary Alveolar Bone Regeneration
- Letter: The Effects of Combined Treatment of Alendronate Plus Active or Plain Vitamin D on the Vitamin D Metabolism and Bone Turnover Marker in Patients with Osteoporosis (Endocrinol Metab 25:305-309, 2010, Jee-Hoon Koo et al.)
- Therapeutic Effect according to Estrogen Dosage on Combined Therapy with Estrogen and Alendronate in Postmenopausal Osteoporosis
