J Korean Neurol Assoc.
2022 Feb;40(1):60-62. 10.17340/jkna.2022.1.9.
Anti-Hu Antibody-Mediated Myelopathy Associated with Gastric Adenocarcinoma
- Affiliations
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- 1Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea
- 2Department of Hemato-oncology, Pusan National University Yangsan Hospital, Yangsan, Korea
- 3Department of Pathology, Pusan National University Yangsan Hospital, Yangsan, Korea
- KMID: 2525354
- DOI: http://doi.org/10.17340/jkna.2022.1.9
Abstract
- Anti-Hu antibody causes paraneoplastic syndrome of the nervous system. Most of the anti-Hu antibodies are found with small cell lung cancer, but can rarely be found with other cancers such as non-small cell lung cancer, prostate cancer, and breast cancer. We report a 57-year-old male patient with advanced gastric adenocarcinoma who had paresthesia and limb ataxia. Electrophysiologic study and imaging showed peripheral neuropathy accompanied with myelitis. Anti-Hu antibody was detected in the patient’s serum, leading to the diagnosis of paraneoplastic syndrome.
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