Korean J Psychosom Med.  2021 Dec;29(2):86-94. 10.22722/KJPM.2021.29.2.86.

Management of Weight Gain and Obesity Associated With Antipsychotics

• Lee NH
• Lee JC

• KMID: 2524468
• DOI: http://doi.org/10.22722/KJPM.2021.29.2.86

Abstract

Objectives
：The risk of weight gain is high when using antipsychotic drugs, and the prevalence of obesity in people with mental illness is high. Obesity management in psychiatric patients is important because obesity causes various complications and lowers treatment adherence and quality of life.
Methods
：In this review, we summarized the management strategies for obesity that can occur when using antipsychotic drugs through a web search.
Results
：Evaluate obesity-related risk factors and related indicators from the beginning of treatment, and conduct regular monitoring. If an antipsychotic drug is used and obesity is induced, a change to a drug with a low metabolic risk may be attempted. Sufficient interventions are also needed on the need to manage obesity, a healthy diet, and exercises in patients and their families. If weight loss is not achieved and obesity-related complications are associated, the use of anti-obesity drugs may be considered. Pharmacological treatment approaches should be carefully considered.
Conclusions
：Non-pharmacological and pharmacological therapies can be applied to manage weight gain and obesity caused by the use of antipsychotic drugs. When using anti-obesity drugs, the characteristics of mental disorders, drug safety, and drug interactions should be considered.

Keyword

Obesity management; Weight gain; Antipsychotics