Neurospine.  2021 Dec;18(4):778-785. 10.14245/ns.2142720.360.

Complications of Posterior Fusion for Atlantoaxial Instability in Children With Down Syndrome

Affiliations
  • 1Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • 2Department of Orthopaedic Surgery, National Hospital Organization Kobe Medical Center, Kobe, Japan
  • 3Department of Orthopaedic Surgery, Kindai University Hospital, Osaka-Sayama, Japan
  • 4Department of Orthopaedic Surgery, Kobe Children’s Hospital, Kobe, Japan

Abstract


Objective
To clarify the complications of posterior fusion for atlantoaxial instability (AAI) in children with Down syndrome and to discuss the significance of surgical intervention.
Methods
Twenty pediatric patients with Down syndrome underwent posterior fusion for AAI between February 2000 and September 2018 (age, 6.1 ± 1.9 years). C1–2 or C1–3 fusion and occipitocervical fusion were performed in 14 and 6 patients, respectively. The past medical history, operation time, estimated blood loss (EBL), duration of Halo vest immobilization, postoperative follow-up period, and intra- and perioperative complications were examined.
Results
The operation time was 257.9 ± 55.6 minutes, and the EBL was 101.6 ± 77.9 mL. Complications related to the operation occurred in 6 patients (30.0%). They included 1 major complication (5.0%): hydrocephalus at 3 months postoperatively, possibly related to an intraoperative dural tear. Other surgery-related complications included 3 cases of superficial infections, 1 case of bone graft donor site deep infection, 1 case of C2 pedicle fracture, 1 case of Halo ring dislocation, 1 case of pseudoarthrosis that required revision surgery, and 1 case of temporary neurological deficit after Halo removal at 2 months postoperatively. Complications unrelated to the operation included 2 cases of respiratory infections and 1 case of implant loosening due to a fall at 9 months postoperatively.
Conclusion
The complication rate of upper cervical fusion in patients with Down syndrome remained high; however, major complications decreased substantially. Improved intra- and perioperative management facilitates successful surgical intervention for upper cervical instability in pediatric patients with Down syndrome.

Keyword

Pediatric Down syndrome; Surgical complication; Atlantoaxial instability; Posterior fusion; Atlantodental interval; Cervical spine
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