World J Mens Health.
2022 Jan;40(1):30-37. 10.5534/wjmh.210056.
Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines
- Agarwal A
1 - Farkouh A1
- Parekh N2
- Zini A3
- Arafa M1,4,5
- Kandil H6
- Tadros N7
- Busetto GM8
- Ambar R9
- Parekattil S10
- Boitrelle F11
- Sallam H12
- Jindal S13
- Ko E14
- Simopoulou M15
- Park HJ16,17
- Ali Sadighi M18
- Saleh R19
- Ramsay J20
- Martinez M21
- Elbardisi H4,22
- Alvarez J23
- Colpi G24
- Gosalvez J25
- Evenson D26
- Shah R27
- Affiliations
-
- 1American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
- 2Department of Urology, Cleveland Clinic, Cleveland, OH, USA
- 3Department of Surgery, McGill University, Montreal, QC, Canada
- 4Department of Urology, Hamad Medical Corporation, Doha, Qatar
- 5Department of Andrology, Cairo University, Giza, Egypt
- 6Fakih IVF Fertility Center, Abu Dhabi, UAE
- 7Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA
- 8Department of Urology and Renal Transplantation, University of Foggia, Policlinico Riuniti, Foggia, Italy
- 9Department of Urology, Centro Universitario em Saude do ABC, Santo André, Brazil
- 10Avant Concierge Urology & University of Central Florida, Winter Garden, FL, USA
- 11Biologie de la Reproduction - Preservation de la fertilite' - Andrologie - CECOS CHI de Poissy Saint Germain en Laye Universite' Paris, Saclay, France
- 12Department of Obstetrics and Gynaecology, Alexandria University Faculty of Medicine, Alexandria, Egypt
- 13Department of Andrology and Reproductive Medicine, Jindal Hospital, Meerut, India
- 14Department of Urology, Loma Linda University Health, Loma Linda, CA, USA
- 15Department of Experimental Physiology, School of Health Sciences, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece
- 16Department of Urology, Pusan National University School of Medicine, Busan, Korea
- 17Medical Research Institute of Pusan National University Hospital, Busan, Korea
- 18Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
- 19Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt
- 20Department of Andrology, Hammersmith Hospital, London, UK
- 21Section of Urology, University of Santo Tomas Hospital, Manila, Philippines
- 22Department of Urology, Weill Cornell Medical-Qatar, Doha, Qatar
- 23Centro Androgen, La Coruña, Spain and Harvard Medical School, Boston, MA, USA
- 24Andrology and IVF Unit, Procrea Institute, Lugano, Switzerland
- 25Departamento de Biología, Universidad Autónoma de Madrid, Madrid, Spain
- 26SCSA Diagnostics, Brookings, SD, USA
- 27Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India
- KMID: 2523634
- DOI: http://doi.org/10.5534/wjmh.210056
Abstract
- Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessary to aid clinicians in the application of SDF for male fertility evaluation. Two recent clinical practice guidelines were published by Agarwal et al and Esteves et al. In this article, we have evaluated and compared both guidelines. We have found fairly similar recommendations between the two guidelines and have also highlighted the differences between them. Finally, we have summarized and combined the best practice recommendations from both guidelines.
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