Epidemiol Health.
2021;43(1):e2021067. 10.4178/epih.e2021067.
Cohort profile: the Environmental-Pollution-Induced Neurological EFfects (EPINEF) study: a multicenter cohort study of Korean adults
- Jang H
1,2 - Kim W1
- Cho J1,3,4
- Sohn J5
- Noh J1
- Seo G1
- Lee SK6
- Noh Y7
- Oh SS8
- Koh SB9
- Kim HJ10
- Seo SW10
- Kim HH11
- Lee JI12
- Kim SY13
- Kim C1,3
- Affiliations
-
- 1Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea
- 2Department of Public Health, Yonsei University Graduate School, Seoul, Korea
- 3Institute of Human Complexity and Systems Science, Yonsei University, Incheon, Korea
- 4Institute for Environmental Research, Yonsei University College of Medicine, Seoul, Korea
- 5Department of Preventive Medicine, Jeonbuk National University Medical School, Jeonju, Korea
- 6Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- 7Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
- 8Department of Occupational and Environmental Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea
- 9Department of Preventive Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea
- 10Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- 11Department of Information, Communication and Technology Convergence. ICT Environment Convergence, Pyeongtaek University, Pyeongtaek, Korea
- 12Korea Testing and Research Institute, Gwacheon, Korea
- 13Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea
- KMID: 2523355
- DOI: http://doi.org/10.4178/epih.e2021067
Abstract
- The general population is exposed to numerous environmental pollutants, and it remains unclear which pollutants affect the brain, accelerating brain aging and increasing the risk of dementia. The Environmental-Pollution-Induced Neurological Effects study is a multi-city prospective cohort study aiming to comprehensively investigate the effect of different environmental pollutants on brain structures, neuropsychological function, and the development of dementia in adults. The baseline data of 3,775 healthy elderly people were collected from August 2014 to March 2018. The eligibility criteria were age ≥50 years and no self-reported history of dementia, movement disorders, or stroke. The assessment included demographics and anthropometrics, laboratory test results, and individual levels of exposure to air pollution. A neuroimaging sub-cohort was also recruited with 1,022 participants during the same period, and brain magnetic resonance imaging and neuropsychological tests were conducted. The first follow-up environmental pollutant measurements will start in 2022 and the follow-up for the sub-cohort will be conducted every 3-4 years. We have found that subtle structural changes in the brain may be induced by exposure to airborne pollutants such as particulate matter 10 μm or less in diameter (PM10), particulate matter 2.5 μm or less in diameter (PM2.5) and Mn10, manganese in PM10; Mn2.5, manganese in PM2.5. PM10, PM2.5, and nitrogen dioxide in healthy adults. This study provides a basis for research involving large-scale, long-term neuroimaging assessments in community-based populations.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Birth cohort effects on maternal and child environmental health: a systematic review
- Age–period–cohort analysis of asthma, allergic rhinitis, and atopic dermatitis prevalence in Japan
- Integrated dataset of the Korean Genome and Epidemiology Study cohort with estimated air pollution data
- Hazardous Health Effects of Environmental Pollution
- Current State of Research on the Risk of Morbidity and Mortality Associated with Air Pollution in Korea
